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MDM2 and MDMX can interact differently with ARF and members of the p53 family
Members of the p53 family of transcription factors have essential roles in tumor suppression and in development. MDM2 is an essential regulator of p53 that can inhibit the transcriptional activity ofExpand
The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2.
ING1b is a candidate tumor suppressor that can stimulate the transcriptional activity of p53 and inhibit cell proliferation. The molecular basis of how ING1b activates p53 function remains unclear.Expand
How Many Mutant p53 Molecules Are Needed To Inactivate a Tetramer?
ABSTRACT The tumor suppressor p53 is transcription factor composed of four identical subunits. The majority of the mutations in p53 are missense mutations that impair DNA binding. On the other hand,Expand
MDM2 and MDMX bind and stabilize the p53-related protein p73
The p53 gene encodes one of the most important tumor suppressors in human cells and undergoes frequent mutational inactivation in cancers. MDM2, a transcriptional target of p53, binds p53 and canExpand
On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells.
Cyclins and cyclin-dependent kinases (CDKs) are key regulators of the human cell cycle. Here we have directly measured the concentrations of the G(1) and G(2) cyclins and their CDK partners in highlyExpand
Cyclin F Is Degraded during G2-M by Mechanisms Fundamentally Different from Other Cyclins*
Cyclin F, a cyclin that can form SCF complexes and bind to cyclin B, oscillates in the cell cycle with a pattern similar to cyclin A and cyclin B. Ectopic expression of cyclin F arrests the cellExpand
ING1b decreases cell proliferation through p53‐dependent and ‐independent mechanisms
ING1b can stimulate cell cycle arrest, repair, senescence, and apoptosis. The actions of ING1b are attributed to its activation of the tumor suppressor p53. Here we investigate the more subtleExpand
Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms.
Camptothecin and Adriamycin are clinically important inhibitors for topoisomerase (Topo) I and Topo II, respectively. The ataxia-telangiectasia mutated (ATM) product is essential for ionizingExpand
Regulation of Cyclin A-Cdk2 by SCF Component Skp1 and F-Box Protein Skp2
ABSTRACT Cyclin A-Cdk2 complexes bind to Skp1 and Skp2 during S phase, but the function of Skp1 and Skp2 is unclear. Skp1, together with F-box proteins like Skp2, are part of ubiquitin-ligase E3Expand
Differential Mode of Regulation of the Checkpoint Kinases CHK1 and CHK2 by Their Regulatory Domains*
CHK1 and CHK2 are key mediators that link the machineries that monitor DNA integrity to components of the cell cycle engine. Despite the similarity and potential redundancy in their functions, CHK1Expand
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