A. Lasorella

Publications98
h-index37
Citations5,813
Highly Influential Citations340
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Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma
Oncogenic TACC-tics Human cancers exhibit many types of genomic rearrangements—including some that juxtapose sequences from two unrelated genes—thereby creating fusion proteins with oncogenic… Expand
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Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
In mammalian cells, Id proteins coordinate proliferation and differentiation. Id2 is a dominant-negative antagonist of basic helix–loop–helix transcription factors and proteins of the retinoblastoma… Expand
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The integrated landscape of driver genomic alterations in glioblastoma
Glioblastoma is one of the most challenging forms of cancer to treat. Here we describe a computational platform that integrates the analysis of copy number variations and somatic mutations and… Expand
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Clonal evolution of glioblastoma under therapy
Glioblastoma (GBM) is the most common and aggressive primary brain tumor. To better understand how GBM evolves, we analyzed longitudinal genomic and transcriptomic data from 114 patients. The… Expand
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The ID proteins: master regulators of cancer stem cells and tumour aggressiveness
Inhibitor of DNA binding (ID) proteins are transcriptional regulators that control the timing of cell fate determination and differentiation in stem and progenitor cells during normal development and… Expand
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The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein
Development of the nervous system requires that timely withdrawal from the cell cycle be coupled with initiation of differentiation. Ubiquitin-mediated degradation of the N-Myc oncoprotein in neural… Expand
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Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth
In the developing nervous system, Id2 (inhibitor of DNA binding 2, also known as inhibitor of differentiation 2) enhances cell proliferation, promotes tumour progression and inhibits the activity of… Expand
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Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma.
Perturbation of the function of the retinoblastoma (Rb) protein is found in most human tumors. Id2 is a natural target of the Rb protein that is recruited by Myc oncoproteins to bypass the tumor… Expand
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Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
In mammals, the fetal liver is the first site of definitive erythropoiesis—the generation of mature, enucleated red cells. The functional unit for definitive erythropoiesis is the erythroblastic… Expand
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Id proteins at the cross-road of development and cancer
A large body of evidence has been accumulated that demonstrates dominant effects of Id proteins on different aspects of cellular growth. Generally, constitutive expression of Id not only blocks cell… Expand
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