A. Lartigue

Publications56
h-index18
Citations1,518
Highly Influential Citations84
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X-ray Structure and Ligand Binding Study of a Moth Chemosensory Protein*
TLDR
Fluorescence quenching with brominated alkyl alcohols or fatty acids and modeling studies indicates that CSPMbraA6 is able to bind such compounds with C12–18 alkyL chains.
mRNA deep sequencing reveals 75 new genes and a complex transcriptional landscape in Mimivirus.
TLDR
This RNA-seq study confirmed the AAAATTGA sequence as an early promoter element, as well as the presence of palindromes at most of the polyadenylation sites, and revealed a new promoter element correlating with late gene expression, which is also prominent in Sputnik, the recently described Mimivirus "virophage".
Revisiting the Specificity of Mamestra brassicaeand Antheraea polyphemus Pheromone-binding Proteins with a Fluorescence Binding Assay*
TLDR
Investigation of the binding properties and specificity of PBPs from Mamestra brassicae, Antheraea polyphemus, Bombyx mori, and a hexa-mutant of MbraPBP1, indicates that relatively limited modifications to the PBP cavity actually interfere with AMA binding, suggesting that AMA binds in the internal cavity.
Moth chemosensory protein exhibits drastic conformational changes and cooperativity on ligand binding
TLDR
The x-ray structure of CSPMbraA6, a 112-aa antennal protein from the moth Mamestra brassicae (Mbra), was shown to exhibit a novel type of α-helical fold and binding cooperativity was demonstrated for some ligands, suggesting a stepwise binding.
In-depth study of Mollivirus sibericum, a new 30,000-y-old giant virus infecting Acanthamoeba
TLDR
Mollivirus sibericum, a fourth type of giant virus, was isolated from the same permafrost sample and analyzed using a combination of “omic” approaches that revealed how the virus highjacks its host machinery to actively replicate.
The Crystal Structure of a Cockroach Pheromone-binding Protein Suggests a New Ligand Binding and Release Mechanism*
TLDR
Differences between LmaPBP and BmorPBP structures suggest that different binding and release mechanism may be adapted to the hydrophilicity or hydrophobicity of the pheromonal ligand.
Mimivirus and Mimiviridae: giant viruses with an increasing number of potential hosts, including corals and sponges.
Diversity and evolution of the emerging Pandoraviridae family
TLDR
It is suggested that de novo gene creation could contribute to the evolution of the giant pandoravirus genomes because most of the strain-specific genes have no extant homolog and exhibit statistical features comparable to intergenic regions.
Sulfur Single-wavelength Anomalous Diffraction Crystal Structure of a Pheromone-Binding Protein from the Honeybee Apis mellifera L*
TLDR
The crystal structure of a PBP originating from the honey-bee antennae and expressed as recombinant protein in the yeast Pichia pastoris is reported, and the structure has been refined at 1.6-Å resolution.
Sulfur Single-wavelength Anomalous Diffraction Crystal Structure of a Pheromone-Binding Protein from the Honeybee Apis mellifera L
TLDR
The crystal structure of a PBP (Amel-ASP1) originating from the honey-bee antennae and expressed as recombinant protein in the yeast Pichia pastoris is reported, illustrating the binding versatility of PBPs.
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