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Von Hippel–Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma
Von Hippel–Lindau disease (VHL) is an autosomal dominant disorder with inherited susceptibility to various forms of cancer, including hemangioblastomas of the central nervous system,Expand
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Community Mental Health in Canada: Policy, Theory and Practice
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Common pathogenetic mechanism for three tumor types in bilateral acoustic neurofibromatosis.
Bilateral acoustic neurofibromatosis (BANF) is a genetic defect associated with multiple tumors of neural crest origin. Specific loss of alleles from chromosome 22 was detected with polymorphic DNAExpand
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A comparison of the pulmonary toxicity produced by metal-free and copper-complexed analogs of bleomycin and phleomycin.
Abstract Previous studies from this laboratory indicated that the terminal amine groups adjacent to the thiazole rings of bleomycins are important determinants of pulmonary toxicity. The presentExpand
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DNA linkage analysis in Von Recklinghausen neurofibromatosis.
We have used DNA linkage analysis in 11 families with Von Recklinghausen neurofibromatosis (VRNF) in order to search for the chromosomal localisation of the defective gene causing this seriousExpand
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Murine immune responses to Schistosoma haematobium and the vaccine candidate rSh28GST.
Longitudinal studies of Schistosoma haematobium infection in CBA mice revealed a progressive down-regulation of cellular immune responses, as measured by mitogenic and antigenic stimulation of inExpand
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Miller's Nursing for Wellness in Older Adults
Miller's Nursing for Wellness in Older Adults was adapted for the Canadian audience with its focus on the older Canadian and the professional Canadian based nurse. This Canadian approach enablesExpand
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Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17.
The mutant gene causing von Recklinghausen neurofibromatosis (NF1) was recently shown to map to chromosome 17. We have used additional markers for chromosome 17 to narrow further the location of theExpand
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Amplification of the antitumor activity of phleomycins and bleomycins in rats and mice by caffeine.
While having no antitumor effect per se, caffeine substantially enhanced the antitumor effects of the phleomycins PLM-CHP and PLM-PEP, and the bleomycins BLM-CHP and Blenoxane in rats carrying WalkerExpand
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Effects of pancreatic spasmolytic Polypeptide (PSP) on epithelial cell function.
Trefoil peptides are expressed near endodermal ulcerations and may modulate epithelial repair. The trefoil pancreatic spasmolytic polypeptide (PSP) was tested for growth activity in vitro onExpand
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