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International Consensus Statement on Allergy and Rhinology: Rhinosinusitis
Isam Alobid, MD, PhD1, Nithin D. Adappa, MD2, Henry P. Barham, MD3, Thiago Bezerra, MD4, Nadieska Caballero, MD5, Eugene G. Chang, MD6, Gaurav Chawdhary, MD7, Philip Chen, MD8, John P. Dahl, MD,Expand
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Ultrasensitive pheromone detection by mammalian vomeronasal neurons
The vomeronasal organ (VNO) is a chemoreceptive organ that is thought to transduce pheromones into electrical responses that regulate sexual, hormonal and reproductive function in mammals. TheExpand
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Th2 Cytokines associated with Chronic Rhinosinusitis with Polyps Down-Regulate the Antimicrobial Immune Function of Human Sinonasal Epithelial Cells
Background Chronic rhinosinusitis with nasal polyps (CRSwNPs) is a disorder characterized by persistent eosinophilic Th2 inflammation and frequent sinonasal microbial colonization. It has beenExpand
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Central Role of the CNGA4 Channel Subunit in Ca2+-Calmodulin-Dependent Odor Adaptation
Heteromultimeric cyclic nucleotide–gated (CNG) channels play a central role in the transduction of odorant signals and subsequent adaptation. The contributions of individual subunits to nativeExpand
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Chronic Cough Due to Gastroesophageal Reflux in Adults: CHEST Guideline and Expert Panel Report.
BACKGROUND We updated the 2006 ACCP clinical practice guidelines for management of reflux-cough syndrome. METHODS Two population, intervention, comparison, outcome (PICO) questions were addressedExpand
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Classification of Cough as a Symptom in Adults and Management Algorithms: CHEST Guideline and Expert Panel Report
Background We performed systematic reviews using the population, intervention, comparison, outcome (PICO) format to answer the following key clinical question: Are the CHEST 2006 classifications ofExpand
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Serum Amyloid A, Properdin, Complement 3, and Toll-Like Receptors are Expressed Locally in Human Sinonasal Tissue
Background There is a growing appreciation of the role that nasal mucosa plays in innate immunity. In this study, the expression of pattern recognition receptors known as toll-like receptors (TLRs)Expand
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Sinonasal Epithelial Cell Expression of Toll-Like Receptor 9 is Decreased in Chronic Rhinosinusitis with Polyps
Background Innate immune recognition of pathogens by sinonasal epithelial cells may play an important role in the pathogenesis of chronic rhinosinusitis (CRS). Previous studies have indicated thatExpand
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Innate immunity of the sinonasal cavity and its role in chronic rhinosinusitis
Chronic rhinosinusitis (CRS) is one of the most common health problems in the United States. Medical therapy and surgery are successful in treating the majority of patients with sinusitis; however,Expand
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Anatomy and Neurophysiology of Cough
Abstract Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive myelinated sensory nerves play essential roles in regulating cough. These vagal sensory nerves terminateExpand
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