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Causes and outcomes of markedly elevated C-reactive protein levels.
OBJECTIVE To characterize the causes of marked elevation of C-reactive protein (CRP) levels, investigate patient outcomes, and examine factors that might influence the CRP response. DESIGN HealthExpand
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Multimorbidity states associated with higher mortality rates in organ dysfunction and sepsis: a data-driven analysis in critical care
BackgroundSepsis remains a complex medical problem and a major challenge in healthcare. Diagnostics and outcome predictions are focused on physiological parameters with less consideration given toExpand
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Using artificial neural networks to identify patients with concussion and postconcussion syndrome based on antisaccades.
OBJECTIVEArtificial neural networks (ANNs) have shown considerable promise as decision support tools in medicine, including neurosurgery. However, their use in concussion and postconcussion syndromeExpand
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Landscape of immune cell gene expression is unique in predominantly WHO grade 1 skull base meningiomas when compared to convexity
Modulation of tumor microenvironment is an emerging frontier for new therapeutics. However in meningiomas, the most frequent adult brain tumor, the correlation of microenvironment with tumorExpand
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“Skull base meningiomas have a distinct immune landscape.”
Modulation of tumor microenvironment is an emerging frontier for new therapeutics. However in meningiomas, the most frequent adult brain tumor, the correlation of microenvironment with tumorExpand
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Data Driven Analysis Reveals Shared Transcriptome Response, Immune Cell Composition, and Distinct Mortality Rates Across Differing Etiologies of Critical Illness
Supplemental Digital Content is available in the text. Objectives: Sepsis and trauma are common health problems and provide great challenges in critical care. Diverse patient responses to theseExpand
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Distinct regional ontogeny and activation of tumor associated macrophages in human glioblastoma
Tumor-associated macrophages (TAMs) constitute up to 50% of tumor bulk in glioblastoma (GBM) and play an important role in tumor maintenance and progression. The recently discovered differencesExpand
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Reclassification of breast cancer: Towards improved diagnosis and outcome
Background The subtyping of breast cancer based on features of tumour biology such as hormonal receptor and HER2 status has led to increasingly patient-specific treatment and thus improved outcomes.Expand
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“Homogenous subgroups of atypical meningiomas defined using oncogenic signatures: basis for a new grading system?”
Meningiomas are the most common brain tumor with a prevalence of 3% in the population. Histological grading of meningiomas (1 through 3) has a major role in determining treatment choice andExpand
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Meta-gene markers predict meningioma recurrence with high accuracy
Background Meningiomas, the most common adult brain tumors, recur in up to half of cases[1–3]. This requires timely intervention and therefore accurate risk assessment of recurrence is essential. OurExpand
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