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Homer: a protein that selectively binds metabotropic glutamate receptors
TLDR
A novel dendritic protein, Homer, is reported that contains a single, PDZ-like domain and binds specifically to the carboxy terminus of phosphoinositide-linked metabotropic glutamate receptors, suggesting that Homer mediates a novel cellular mechanism that regulates glutamate signalling.
GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors
TLDR
GRIP is a new member of the PDZ domain-containing protein family which has seven PDZ domains and no catalytic domain and appears to serve as an adapter protein that links AMPA receptors to other proteins and may be critical for the clustering of AMPA receptor at excitatory synapses in the brain.
A huntingtin-associated protein enriched in brain with implications for pathology
TLDR
The identification of a protein (huntingtin-associated protein (HAP)-l) that binds to huntingtin is reported, enhanced by an expanded polyglutamine repeat, the length of which is also known to correlate with the age of disease onset19–21.
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
TLDR
HAP1 might function as an adaptor protein using coiled coils to mediate interactions among cytoskeletal, vesicular and motor proteins, which could contribute to the neuronal dysfunction and death seen in HD.
Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions
TLDR
It is found that α-synuclein interacts in vivo with synphilin-1 in neurons, and co-transfection of both proteins (but not control proteins) in HEK 293 cells yields cytoplasmic eosinophilic inclusions.
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