Decisional capacity for informed consent in schizophrenia research.
The decisional capacity for informed consent in schizophrenic research subjects is ascertained, to determine if reduced capacity relates to specific aspects of psychopathologic features and to test the hypothesis that reduced capacity can be remediated with an educational informed consent process.
Effects of Ketamine in Normal and Schizophrenic Volunteers
Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia
Ketamine activates psychosis and alters limbic blood flow in schizophrenia
The non-competitive NMDA antagonist ketamine, given to schizophrenic individuals in subanesthetic doses, produced a short-lived, discrete activation of their psychotic symptoms, which had striking…
Neurometabolites in schizophrenia and bipolar disorder — A systematic review and meta-analysis
Spatial and Temporal Mapping of De Novo Mutations in Schizophrenia to a Fetal Prefrontal Cortical Network
Functional effects of antipsychotic drugs: comparing clozapine with haloperidol
Effects of Noncompetitive NMDA Receptor Blockade on Anterior Cingulate Cerebral Blood Flow in Volunteers with Schizophrenia
- H. Holcomb, A. Lahti, D. Medoff, T. Cullen, C. Tamminga
- Psychology, MedicineNeuropsychopharmacology
- 1 December 2005
It is hypothesized that ketamine antagonizes an NMDAR-dependent inhibitory system that is partially compromised in subjects with schizophrenia, and the ketamine-induced reduction of inhibition leads to a marked increase in glutamate release and hypermetabolism in frontal and cingulate cortical regions.
The effects of a subanesthetic dose of ketamine on verbal memory in normal volunteers
This study characterizes the behavioral effects associated with ketamine and suggests that ketamine decreases verbal memory performance by interfering with early consolidation processes.
Gamma and Delta Neural Oscillations and Association with Clinical Symptoms under Subanesthetic Ketamine
Several electrical neural oscillatory abnormalities have been associated with schizophrenia, although the underlying mechanisms of these oscillatory problems are unclear. Animal studies suggest that…