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Increased Risk of Psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population
TLDR
Integration of genetic and gene expression data allowed us to identify the actual disease variants at the LCE3 cluster among the psoriasis patients in India. Expand
Endoplasmic reticulum stress is transmissible in vitro between cells of the central nervous system
TLDR
Insight is provided into the cell non‐autonomous influence of ER stress on cells of the central nervous system by indicating that ER‐stressed astrocytes and neurons secrete a molecule(s) with lipid characteristics which regulates both inflammatory and ER stress responses in other astroCytes, neurons, and microglia in vitro. Expand
Genetics of Psoriasis
TLDR
Several genetic susceptibility loci show differential associations between ethnic populations, suggesting potential genetic heterogeneity of psoriasis across diverse ancestries, and HLA-Cw6 allele is the most important risk allele within the MHC Class I region. Expand