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Unus pro omnibus, omnes pro uno: A novel, evidence-based, unifying theory for the pathogenesis of endometriosis.
The theory of retrograde menstruation as aetiopathogenesis of endometriosis formulated by John Sampson in 1927 shows clear shortcomings: this does not explain why retrograde menstruation is a… Expand
Vitamin B12 among Vegetarians: Status, Assessment and Supplementation
Cobalamin is an essential molecule for humans. It acts as a cofactor in one-carbon transfers through methylation and molecular rearrangement. These functions take place in fatty acid, amino acid and… Expand
The Pleiotropic Effects of Vitamin D in Gynaecological and Obstetric Diseases: An Overview on a Hot Topic
- Francesca Colonese, A. Laganà, +4 authors O. Triolo
- Biology, Medicine
- BioMed research international
- 27 April 2015
The traditionally recognized role of vitamin D consists in the regulation of bone metabolism and calcium-phosphorus homeostasis but recently a lot of in vitro and in vivo studies recognized several… Expand
Endometrial scratch injury before intrauterine insemination: is it time to re-evaluate its value? Evidence from a systematic review and meta-analysis of randomized controlled trials.
OBJECTIVE To assess the impact of endometrial scratch injury (ESI) on the outcomes of intrauterine insemination (IUI) stimulated cycles. DESIGN Systematic review and meta-analysis. SETTING Not… Expand
Myo-inositol as a male fertility molecule: speed them up!
- R. Condorelli, S. La Vignera, +4 authors A. Calogero
- European review for medical and pharmacological…
Myo-inositol (MYO) usually represents a therapeutic option for female infertility associated with insulin resistance. Recently, several evidences are accumulating about the potential use of MYO for… Expand
Ureteroscopy in pregnant women with complicated colic pain: Is there any risk of premature labor?
- S. Butticè, A. Laganà, +8 authors T. E. Şener
- Archivio italiano di urologia, andrologia…
- 31 December 2017
OBJECTIVE Clinical presentation of ureteral stones during pregnancy is generally with renal colic pain. The aim of this study is to present our experience in the management of renal colic during… Expand
Epigenetic and genetic landscape of uterine leiomyomas: a current view over a common gynecological disease
- A. Laganà, D. Vergara, +8 authors S. Vitale
- Archives of Gynecology and Obstetrics
- 5 September 2017
PurposeDespite the numerous studies on the factors involved in the genesis and growth of uterine leiomyomas, the pathogenesis of these tumors remains unknown. Intrinsic abnormalities of the… Expand
Behavior of Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptor 1/Tumor Necrosis Factor Receptor 2 System in Mononuclear Cells Recovered From Peritoneal Fluid of Women With Endometriosis at…
During endometriosis, a breakdown occurs in endometrial and peritoneal homeostasis caused by cytokine-induced cell proliferation and dysregulation of apoptosis. We studied tumor necrosis factor… Expand
Pleiotropic Actions of Peroxisome Proliferator-Activated Receptors (PPARs) in Dysregulated Metabolic Homeostasis, Inflammation and Cancer: Current Evidence and Future Perspectives
- A. Laganà, S. Vitale, +8 authors M. Buscema
- Medicine, Biology
- International journal of molecular sciences
- 24 June 2016
Background: Peroxisome proliferator-activated receptors (PPARs) have demonstrated a lot of important effects in the regulation of glucose and lipid metabolism and in the correct functioning of… Expand
Inositol’s and other nutraceuticals’ synergistic actions counteract insulin resistance in polycystic ovarian syndrome and metabolic syndrome: state-of-the-art and future perspectives
- C. Paul, A. Laganà, P. Maniglio, O. Triolo, D. M. Brady
- Gynecological endocrinology : the official…
- 29 February 2016
Abstract The incidence of metabolic syndrome (MetS), type II diabetes (T2D) and polycystic ovarian syndrome (PCOS) has been progressively increasing. Insulin resistance (InsR) seems to play a key… Expand