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Recurrent Hypoxemia in Children Is Associated with Increased Analgesic Sensitivity to Opiates
Background: Postsurgical administration of opiates in patients with obstructive sleep apnea (OSA) has recently been linked to an increased risk for respiratory complications. The authors haveExpand
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Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate
J. Neurochem. (2010) 113, 552–561.
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PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain
BackgroundChronic pain occurs when normally protective acute pain becomes pathologically persistent. We examined here whether an isoform of protein kinase C (PKC), PKMζ, that underlies long-termExpand
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Cutaneous tactile allodynia associated with microvascular dysfunction in muscle
BackgroundCutaneous tactile allodynia, or painful hypersensitivity to mechanical stimulation of the skin, is typically associated with neuropathic pain, although also present in chronic pain patientsExpand
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Microdialyzed adenosine in nucleus tractus solitarii and ventilatory response to hypoxia in piglets.
Levels of adenosine, inosine, and hypoxanthine from the interstitial space at the nucleus tractus solitarii were measured by microdialysis in eight 20- to 25-day-old anesthetized spontaneouslyExpand
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Recurrent Hypoxemia in Young Children with Obstructive Sleep Apnea Is Associated with Reduced Opioid Requirement for Analgesia
BackgroundObstructive sleep apnea (OSA) in children is often associated with recurrent hypoxemia during sleep. In developing animals, central opioid neuropeptide content is high, and opioid receptorsExpand
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Role of peripheral endothelin receptors in an animal model of complex regional pain syndrome type 1 (CRPS-I)
&NA; Chronic post‐ischemic pain (CPIP) is an animal model of CRPS‐I developed using a 3‐h ischemia–reperfusion injury of the rodent hind paw. The contribution of local endothelin to nociception hasExpand
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Recurrent Hypoxia in Rats during Development Increases Subsequent Respiratory Sensitivity to Fentanyl
Background: In children with a history of significant obstructive sleep apnea who undergo adenotonsillectomy, postsurgical administration of opiates has been alleged to be associated with anExpand
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Topical combinations aimed at treating microvascular dysfunction reduce allodynia in rat models of CRPS-I and neuropathic pain.
UNLABELLED Growing evidence indicates that various chronic pain syndromes exhibit tissue abnormalities caused by microvasculature dysfunction in the blood vessels of skin, muscle, or nerve. We testedExpand
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