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Recurrent Hypoxemia in Children Is Associated with Increased Analgesic Sensitivity to Opiates
Background: Postsurgical administration of opiates in patients with obstructive sleep apnea (OSA) has recently been linked to an increased risk for respiratory complications. The authors have… Expand
Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate
- N. Kumar, A. Laferrière, J. Yu, A. Leavitt, T. J. Coderre
- Journal of neurochemistry
- 1 April 2010
J. Neurochem. (2010) 113, 552–561.
PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain
BackgroundChronic pain occurs when normally protective acute pain becomes pathologically persistent. We examined here whether an isoform of protein kinase C (PKC), PKMζ, that underlies long-term… Expand
Cutaneous tactile allodynia associated with microvascular dysfunction in muscle
BackgroundCutaneous tactile allodynia, or painful hypersensitivity to mechanical stimulation of the skin, is typically associated with neuropathic pain, although also present in chronic pain patients… Expand
Microdialyzed adenosine in nucleus tractus solitarii and ventilatory response to hypoxia in piglets.
- S. Yan, A. Laferrière, C. Zhang, I. R. Moss
- Biology, Medicine
- Journal of applied physiology
- 1 August 1995
Levels of adenosine, inosine, and hypoxanthine from the interstitial space at the nucleus tractus solitarii were measured by microdialysis in eight 20- to 25-day-old anesthetized spontaneously… Expand
Recurrent Hypoxemia in Young Children with Obstructive Sleep Apnea Is Associated with Reduced Opioid Requirement for Analgesia
BackgroundObstructive sleep apnea (OSA) in children is often associated with recurrent hypoxemia during sleep. In developing animals, central opioid neuropeptide content is high, and opioid receptors… Expand
Role of peripheral endothelin receptors in an animal model of complex regional pain syndrome type 1 (CRPS-I)
&NA; Chronic post‐ischemic pain (CPIP) is an animal model of CRPS‐I developed using a 3‐h ischemia–reperfusion injury of the rodent hind paw. The contribution of local endothelin to nociception has… Expand
Recurrent Hypoxia in Rats during Development Increases Subsequent Respiratory Sensitivity to Fentanyl
Background: In children with a history of significant obstructive sleep apnea who undergo adenotonsillectomy, postsurgical administration of opiates has been alleged to be associated with an… Expand
Metabotropic glutamate receptors (mGluRs) regulate noxious stimulus‐induced glutamate release in the spinal cord dorsal horn of rats with neuropathic and inflammatory pain
- N. Kumar, A. Laferrière, J. Yu, Tanya Poon, T. J. Coderre
- Chemistry, Medicine
- Journal of neurochemistry
- 1 July 2010
J. Neurochem. (2010) 114, 281–290.
Topical combinations aimed at treating microvascular dysfunction reduce allodynia in rat models of CRPS-I and neuropathic pain.
- J. V. Ragavendran, A. Laferrière, +4 authors T. J. Coderre
- The journal of pain : official journal of the…
UNLABELLED Growing evidence indicates that various chronic pain syndromes exhibit tissue abnormalities caused by microvasculature dysfunction in the blood vessels of skin, muscle, or nerve. We tested… Expand