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Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment
We evaluated the effect of Alzheimer's disease (AD) susceptibility loci on endophenotypes closely related with AD pathology in patients with mild cognitive impairment (MCI).
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Genome-wide significant risk factors for Alzheimer's disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment
Few data are available concerning the role of risk markers for Alzheimer’s disease (AD) in progression to AD dementia among subjects with mild cognitive impairment (MCI). We therefore investigatedExpand
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The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders
Major mood disorders, which primarily include bipolar disorder and major depressive disorder, are the leading cause of disability worldwide and pose a major challenge in identifying robust riskExpand
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Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene
To follow-up loci discovered by the International Genomics of Alzheimer’s Disease Project, we attempted independent replication of 19 single nucleotide polymorphisms (SNPs) in a large Spanish sampleExpand
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SUCLG 2 identified as both a determinator of CSF A b 1 – 42 levels and an attenuator of cognitive decline in Alzheimer ’ s disease
Alfredo Ramirez1,2,,∗, Wiesje M. van der Flier6,7,, Christine Herold8,, David Ramonet3,, Stefanie Heilmann2,4, Piotr Lewczuk9, Julius Popp1, André Lacour8, Dmitriy Drichel8, Eva Louwersheimer6,7,Expand
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Genome-wide association study using cerebrospinal fluid biomarkers beta-amyloid-42 and pTau181 in German samples of Alzheimer's disease
CEREBROSPINAL FLUID BIOMARKERS BETAAMYLOID-42 AND PTAU181 IN GERMAN SAMPLES OFALZHEIMER’S DISEASE Alfredo Ramirez, Christine Herold, Piotr Lewczuk, Andr e Lacour, Dmitriy Drichel, Britta Sch€urmann,Expand
Genome-wide significant risk factors for Alzheimer’s disease: role in progression to dementia due to AD among subjects with mild cognitive impairment
A. Lacour*, A. Espinosa*, E. Louwersheimer, S. Heilmann, I. Hernández, S. Wolfsgruber, V. Fernández, H. Wagner, M. Rosende-Roca, A. Mauleón, S. Moreno-Grau, L. Vargas, Y.A.L. Pijnenburg, T. Koene, O.Expand
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Contents Vol. 78, 2014
A four-center study on the effect of polygenic risk score on cerebrospinal fluid markers and memory decline in mild cognitive impairment patients
associated with Alzheimer’s disease (AD), independent of biomarkers of AD pathology. Genetic factors play a significant role in WMH etiology, yet common genetic variants identified by GWAS explainExpand
Novel e subunit mutation of the muscle
substantia nigra pars compacta, pontine nuclei and inferior olivary nuclei, marked Purkinje-cell loss and demyelination of cerebellar white matter. Immunohistochemistry for a-synuclein (SNCA)Expand