A. L. Winther

Publications31
h-index10
Citations1,178
Highly Influential Citations76
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The sarcoplasmic Ca2+-ATPase: design of a perfect chemi-osmotic pump.
The sarcoplasmic (SERCA 1a) Ca2+-ATPase is a membrane protein abundantly present in skeletal muscles where it functions as an indispensable component of the excitation-contraction coupling, being at… Expand
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The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm
The contraction and relaxation of muscle cells is controlled by the successive rise and fall of cytosolic Ca2+, initiated by the release of Ca2+ from the sarcoplasmic reticulum and terminated by… Expand
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The structural basis of calcium transport by the calcium pump
The sarcoplasmic reticulum Ca2+-ATPase, a P-type ATPase, has a critical role in muscle function and metabolism. Here we present functional studies and three new crystal structures of the rabbit… Expand
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The structural basis of calcium transport by the calcium pump
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Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation
The first crystal structure of the neurotransmitter/sodium symporter homolog LeuT revealed an occluded binding pocket containing leucine and 2 Na+; later structures showed tricyclic antidepressants… Expand
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Chloride binding site of neurotransmitter sodium symporters
Neurotransmitter:sodium symporters (NSSs) play a critical role in signaling by reuptake of neurotransmitters. Eukaryotic NSSs are chloride-dependent, whereas prokaryotic NSS homologs like LeuT are… Expand
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Critical Roles of Hydrophobicity and Orientation of Side Chains for Inactivation of Sarcoplasmic Reticulum Ca2+-ATPase with Thapsigargin and Thapsigargin Analogs*
Thapsigargin (Tg), a specific inhibitor of sarco/endoplasmic Ca2+-ATPases (SERCA), binds with high affinity to the E2 conformation of these ATPases. SERCA inhibition leads to elevated calcium levels… Expand
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Identification of Antifungal H+-ATPase Inhibitors with Effect on Plasma Membrane Potential
ABSTRACT The plasma membrane H+-ATPase (Pma1) is an essential fungal protein and a proposed target for new antifungal medications. The compounds in a small-molecule library containing ∼191,000… Expand
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A first low-resolution difference Fourier map of phosphorus in a membrane protein from near-edge anomalous diffraction.
Crystal diffraction of three membrane proteins (cytochrome bc(1) complex, sarcoplasmic reticulum Ca(2+) ATPase, ADP-ATP carrier) and of one nucleoprotein complex (leucyl tRNA synthetase bound to… Expand
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Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity
We have identified a series of tetrahydrocarbazoles as novel P-type ATPase inhibitors. Using a set of rationally designed analogues, we have analyzed their structure-activity relationship using… Expand
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