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Effects of Cholinotropic and Cytostatic Drugs on the Development of Arthus Reaction
Apoptosis of tumor cell and inhibition of inflammation can be essential for chemotherapy of malignant and autoimmune diseases. Expand
[Modulation of the cholinergic system during inflammation].
The role of immune system in the pathogenesis of endotoxic shock is associated with the production of proinflammatory cytokines by macrophages, increase in IgM concentration, and complement activation, while the role in thePathogenesis of anaphylactic shock isassociated with IgE, IgG1 augmentation. Expand
[Antianaphylactic effects of muscarinic antagonists].
Cholinergic drugs modulate the immunological and pathochemical stages of anaphylactic shock and resulted in normalization of B cell activity and 5-HT level in the spleen in guinea pigs which survived shock. Expand
Cholinergic modulation of anaphylactic shock: plasma proteins influence.
The combination of methacine with neostigmine can regulate the pathochemical stage of shock and the 5-HT release and increases the antianaphylactic activity of methamphetamine, but albumin and CRP abolish it. Expand
[Non-neuronal effects of muscarinic antagonists in the prophylaxis of stress].
Determination of the drug influence on the systemic immune response allows one to predict the non-neuronal effects of cholinergic antagonists and, in this way, to affect the pathogenesis of stress gastric ulcer. Expand
Effects of Cholinergic Agonists and Antagonists under Conditions of Spleen Denervation in Rats with Endotoxic Shock
Model experiments on rats with endotoxic shock induced by intraperitoneal injection of LPS Salmonella Typhi strain ty-4441 (20 mg/kg) showed that crossing of the vagus nerve innervating the spleenExpand
Blood plasma proteins modulate the broncholytic effects of a muscarinic receptor antagonist
Blood plasma proteins modulated the effects of muscarinic receptor antagonist methacin and was probably associated with allosteric antagonism to M2 cholinergic receptors on non-nervous cells, which increased antibody production and mediator response. Expand
[Effects of cholinergic drugs and blood plasma proteins on the development of Arthus reaction].
The role of cholinergic system and plasma proteins in the organism sensitization development is demonstrated and ipratropium bromide and CRP prevented Arthus reaction development. Expand
[Anti-inflammatory role of cholinergic and serotonergic systems in shock].
Data show, that inhibition of the central cholinergic mechanisms leads to increase and their excitation--to decrease in activity of the spleen serotonergic system, so, spleen concentration of serotonin is connected with a target of shock defeat (lungs or heart). Expand