• Publications
  • Influence
A Novel Sequence in the Coiled-coil Domain of Stat3 Essential for Its Nuclear Translocation*
Stat3 is activated by cytokines and growth factors via specific tyrosine phosphorylation, dimerization, and nuclear translocation. However, the mechanism involved in its nuclear translocation isExpand
  • 105
  • 9
Structure-activity relationships of antileishmanial and antimalarial chalcones.
A series of oxygenated chalcones which have been evaluated earlier for antimalarial activity (Plasmodium falciparum K1) were tested for antileishmanial activity against Leishmania donovaniExpand
  • 214
  • 4
Essential tension and constructive destruction: the spindle checkpoint and its regulatory links with mitotic exit.
Replicated genetic material must be partitioned equally between daughter cells during cell division. The precision with which this is accomplished depends critically on the proper functioning of theExpand
  • 56
  • 2
The structure of gelsolin bound to ATP.
Calcium activation of the actin-modifying properties of gelsolin is sensitive to ATP. Here, we show that soaking calcium-free gelsolin crystals in ATP-containing media results in ATP occupying a siteExpand
  • 15
  • 1
Antiplasmodial activity of ferrocenyl chalcones: investigations into the role of ferrocene.
  • Xiang Wu, E. Tiekink, +5 authors M. Go
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 1 February 2006
A series of ferrocenyl chalcones were synthesized and evaluated in vitro against Plasmodium falciparum (K1) in a [3H] hypoxanthine uptake assay. Appropriate size, electronic, lipophilic andExpand
  • 98
Structure-activity relationships of some indolo[3,2-c]quinolines with antimalarial activity.
The synthesis, physicochemical characterization and in vitro antimalarial activity of a series of indolo[3,2-c]quinolines (9a-f) are described. There is only a poor correlation between the activityExpand
  • 29
From Aggregates to Clusters. Facile Formation of Hetero-Metal−Metal Bonds through Reductive Desulfurization by CO in a Decapacitative Transformation of a {Pt2MS2} Tbp Frame to a {Pt2MS} Tetrahedral
[Pt2(PPh3)4(μ-S)2] (1) reacts with AgCl(PPh3) and CuCl under a mild pressure of CO (60 psi) to give [Pt2(CO)(PPh3)3(μ3-S)MCl] [M = Ag (4) and Cu (6)] via the intermediatesExpand
  • 29
Formation of [CoPt2Cl2(PPh3)4(µ3-S)2] from facile heterometallation of [Pt2(PPh3)4(µ-S)2] and its facile deheterometallation via carbonylative desulfurization to give Pt–Pt bonded
Metallation of [Pt2(PPh3)4(µ-S)2]1 with CoCl2 gave [CoPt2Cl2(PPh3)4(µ3-S)2]2 at room temperature. Treatment of 2 with CO in an autoclave resulted in a binuclear compound [Pt2(CO)2(PPh3)2(µ-S)]3, viaExpand
  • 15
The Isolobal Theory and Organotransition Metal Chemistry—Some Recent Advances
Abstract Hoffmann's isolobal theory was largely credited for bridging the gap between inorganic complexes and carbon-based compounds. Recent advances have extended its applications toExpand
  • 3