A. L. Santos

Publications30
h-index8
Citations228
Highly Influential Citations8
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Phenotypical properties associated with virulence from clinical isolates belonging to the Candida parapsilosis complex.
The production of virulence attributes in three reference strains and 11 clinical isolates primarily identified as Candida parapsilosis was evaluated. Morphological and phenotypical tests were not… Expand
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Detection of sialoglycomolecules in five plant trypanosomatids and in an insect phytophagous isolate
The sialoglycoprotein profiles of five plant trypanosomatids (Phytomonas spp.) and of one flagellate (Herpetomonas sp.) isolated from the salivary gland of a phytophagous insect (Phthia picta) were… Expand
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Chondrogenesis of the limbs and mesopodial ossification of Podocnemis expansa Schweigger, 1812 (Testudines: Podocnemidae)
We address the chondrogenic formation of the limbs and the mesopodial ossification pattern of the Pleurodira Podocnemis expansa, to resolve the homology of these elements as well as the pattern of… Expand
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In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(II) and silver(I) complexes
1,10-Phenanthroline (phen, 5), 1,10-phenanthroline-5,6-dione (phendione, 6), [Cu(phendione)3](ClO4)2·4H2O (12) and [Ag(phendione)2]ClO4 (13) are highly active, in vitro, against a range of normal and… Expand
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Protease expression by microorganisms and its relevance to crucial physiological/pathological events.
The treatment of infections caused by fungi and trypanosomatids is difficult due to the eukaryotic nature of these microbial cells, which are similar in several biochemical and genetic aspects to… Expand
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Calpains: potential targets for alternative chemotherapeutic intervention against human pathogenic trypanosomatids.
The treatment for both leishmaniasis and trypanosomiasis, which are severe human infections caused by trypanosomatids belonging to Leishmania and Trypanosoma genera, respectively, is extremely… Expand
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Aspartic protease inhibitors: effective drugs against the human fungal pathogen Candida albicans.
Candida albicans can invade humans and may lead to mucosal and skin infections or to deep-seated mycoses of almost all inner organs, especially in immunocompromised patients. In this context, both… Expand
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Insights into the social life and obscure side of Scedosporium/Lomentospora species: ubiquitous, emerging and multidrug-resistant opportunistic pathogens
Abstract The undeniable relevance of fungal infections caused by both yeasts and molds has considerably augmented over the last four decades, becoming a serious health public problem in hospitals… Expand
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Aspartic Peptidase Inhibitors as Potential Bioactive Pharmacological Compounds Against Human Fungal Pathogens
The development of novel antifungal drugs is becoming more demanding every day since existing drugs either have too many side-effects or they tend to lose effectiveness due to resistant fungal… Expand
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Biological Roles of Peptidases in Trypanosomatids
In this review, we report the recent developments in the characterization of peptidases and their possible biological functions in the Trypanosomatidae family. The focus will be on peptidases from… Expand
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