A. L. Goldin

Publications116
h-index52
Citations12,027
Highly Influential Citations613
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International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels
TLDR
The molecular relationships and physiological roles of these sodium channel proteins are presented and comprehensive information on their molecular, genetic, physiological, and pharmacological properties is provided. Expand
Resurgence of sodium channel research.
  • A. L. Goldin
  • Biology, Medicine
  • Annual review of physiology
  • 2001
TLDR
A variety of isoforms of mammalian voltage-gated sodium channels have been described, and the alpha subunit isoforms have distinct patterns of development and localization in the nervous system, skeletal and cardiac muscle. Expand
A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.
TLDR
It is proposed that the hydrophobic cluster of Ile-1488, Phe-1489, and Met-1490 serves as a hydrophilic latch that stabilizes the inactivated state in a hinged-lid mechanism of Na(+)-channel inactivation. Expand
Nomenclature of Voltage-Gated Sodium Channels
TLDR
The present alphabetical nomenclature does not reveal the structural relationships among the α1 subunits of Ca2+ channels, but it is apparent that these two alphabeticals will overlap at α1L, which may not mediate an L-type Ca2- current and therefore may create confusion. Expand
Maintenance of Xenopus laevis and oocyte injection.
TLDR
This chapter explains the maintenance of Xenopus laevis and oocyte injection, which involves injecting frogs with human chorionic gonadotropin, which induces ovulation and egg laying, after which oocyte development starts over approximately synchronously. Expand
Evolution of voltage-gated Na(+) channels.
  • A. L. Goldin
  • Biology, Medicine
  • The Journal of experimental biology
  • 1 March 2002
TLDR
Vertebrate and invertebrate Na(+) channels appear to be derived from a single primordial channel that subsequently evolved independently in the two lineages. Expand
Mechanisms of sodium channel inactivation
  • A. L. Goldin
  • Chemistry, Medicine
  • Current Opinion in Neurobiology
  • 1 June 2003
TLDR
Fast inactivation occurs by a 'hinged lid' mechanism in which an inactivating particle occludes the pore, whereas slow inactivation is most likely to involve a rearrangement of the channel pore. Expand
Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel.
TLDR
Results indicate that the beta 1 subunit is crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the rat brain sodium channel. Expand
Functional Analysis of the Mouse Scn8a Sodium Channel
TLDR
The unique persistent current observed for Scn8a channels is consistent with the hypothesis that this channel is responsible for distinct sodium conductances underlying repetitive firing of action potentials in Purkinje neurons. Expand
Sodium channel SCN1A and epilepsy: Mutations and mechanisms
TLDR
Results from mouse models suggest that the primary effect of both GEFS+ and DS mutations is to decrease the activity of GABAergic inhibitory neurons, and may be a general consequence of SCN1A mutations. Expand
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