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Species differences in phenazeram kinetics and metabolism
- V. Zherdev, S. Caccia, S. Garattini, A. L. Ékonomov
- Biology, MedicineEuropean Journal of Drug Metabolism and…
The results suggest that 3-OH- phenazepam might contribute to the overall pharmacological effects of the parent compound in those species in which it accumulates in significant amounts.
Method of quantitative gas-chromatographic determination of phenazepam and its metabolite 3-hydroxyphenazepam in plasma
The absence of a reliable, highly sensitive, and clinically safe method of quantitative determination of phenazepam in human blood up to this time has inhibited broad investigations of the pharmacokinetics of this preparation.
Actuarial aging rate is not constant within the human life span.
It was found that generally the male aging rate is not constant but lowers monotonically with time, while for females the aging rate has a pronounced approximately-shaped character with a minimum in therange of 45-60 years and a maximum within the range of 70-80 years.
7-Bromo-5-(2'-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (I), a new tranquillizing agent: metabolism in rats.
- A. L. Ékonomov, A. P. Rodionov, V. Zherdev, Y. I. Vikhlyaev
- ChemistryXenobiotica; the fate of foreign compounds in…
After intraperitoneal injection of rats with the new benzodiazepine (compound I), four metabolites (compounds II, III, IV and V) were found in the urine and mass spectra indicate that compound III contains a hydroxyl group in the C(5)-phenyl ring.
[Pharmacokinetics of fenazepam and its metabolite 3-oxyfenazepam in animals of different species and in man].
- V. Zherdev, L. Martynova, S. Caccia, S. Garattini, A. L. Ékonomov
- Biology, MedicineFarmakologiia i toksikologiia
It has been established that phenazepam is rapidly absorbed from the gastrointestinal tract of animals and man and the metabolite 3 + hydroxyphenzepam was identified in appreciable amounts in cat and rat blood.
Metabolism of the new psychotropic agent phenazepam
- A. L. Ékonomov, V. Zherdev, A. P. Rodionov, Y. I. Vikhlyaev
- ChemistryPharmaceutical Chemistry Journal
- 1 July 1979
Phenazepam -7-bromo-5-(2'-chlorophenyl)-l,3-dihydro-2H-l,4-benzdiazepin-2-one (1) -is a new psychotropic agent with pronounced tranquilizing, soporific, and anticonvulsive properties [i, 2]. The…
A model of the kinetics of blood levels of phenazepam and its metabolite 3-hydroxyphenazepam in cats
[The age-related dynamics of mortality and the Gompertz-Makeham law].
Using the statistics of mortality of Caucasian population of 48 states of the USA (1969-1971) it was demonstrated that the real age dynamics of human mortality may differ significantly both from the…
Pharmacokinetics and bioaccessibility of the tranquilizer phenazepam in dogs
- V. Zherdev, A. L. Ékonomov, L. M. Brestkina
- Biology, MedicinePharmaceutical Chemistry Journal
- 1 February 1983
The purpose of the present work was to study the kinetics of unchanged I and its active metabolite II in the blood of dogs, and to determine the nature of the penetration of the drug into the blood when it is taken internally.
[Correlation between the pharmacokinetic indices and the pharmacological effects of fenazepam in an experiment].
- V. Zherdev, T. Voronina, A. L. Ékonomov, L. Martynova
- Psychology, BiologyFarmakologiia i toksikologiia
The magnitude of the myorelaxant effect of phenazepam in rats after its oral and intravenous administration correlated well with the drug concentration in blood only at the late periods of time.