• Publications
  • Influence
Role of Vasopressin in the Regulation of Renal Sodium Excretion: Interaction with Glucagon‐Like Peptide‐1
Data suggest that GLP‐1 combined with vasopressin could be involved in the regulation of sodium balance in the hyperosmolar state as a result of NaCl loading.
Stimulus for Glucagon-Like Peptide 1 Secretion in Rats
A method of short-term increase in the gastric capacity in rats using an inflating balloon attached to the Foley catheter was developed in order to test the hypothesis that excitation of the upper gastrointestinal tract receptors is a primary signal for the GLP-1 secretion during oral intake of the substances.
Physiological mechanisms for the increase in renal solute‐free water clearance by a glucagon‐like peptide‐1 mimetic
The effect of exenatide on solute‐free water clearance in water‐loaded rats is presumably mediated by stimulation of PGE2 secretion and reinforcement of tubular fluid influx from the proximal tubule to the distal segment of the nephron and collecting duct.
Stimulation of glucagon-like peptide-1 secretion by water loading in human
The results provided evidence of the putative role of GLPP1 in water–salt metabolism and its secretion in response to water consumption in order to restore the water balance, and confirmed the hypothesis that water consumption can induce theGLPP1 secretion.
The mechanism of glucagon-like peptide-1 participation in the osmotic homeostasis
Under the water load in rats, exenatide significantly increased the clearance of lithium, reduced fluid re absorption in the proximal tubule of the nephron and intensified reabsorption of sodium ions in the distal parts, which contributed to the formation of sodium-free water and faster recovery of osmotic homeostasis.
Synthesis of new vasotocin analogues: effects on renal water and ion excretion in rats
Vasopressin and nonmammalian hormone vasotocin are known to increase the water permeability of mammalian collecting ducts, frog skin and the urinary bladder. Neurohypophysial nonapeptides have also
Replacement of L-arginine(8) by D-arginine(8) cancels the natriuretic effect of arginine vasotocin analogs in rats
New analogs of this hormone were synthesized to study the specific features of the arginine vasotocin molecule that are important for the physiological effect caused by inhibition of sodium reabsorption in renal tubules.
Subtypes of Neurohypophyseal Nonapeptide Receptors and Their Functions in Rat Kidneys
The spectrum of activated receptor subtypes varies depending on the current concentration of neurohypophyseal hormones, as a result of which the predominant effect on renal function changes, which ensures precise regulation of water-salt homeostasis.
Involvement of Glucagon-Like Peptide-1 in the Regulation of Selective Excretion of Sodium or Chloride Ions by the Kidneys
Findings suggest that glucagon-like peptide-1 participates in selective regulation of the balance of sodium and chloride ions in rats.