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TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells.
- E. Piek, A. Moustakas, A. Kurisaki, C. Heldin, P. ten Dijke
- BiologyJournal of cell science
- 15 December 1999
TGF-(beta)1 signals potently and passes the activation threshold to evoke NMuMG cell transdifferentiation and induced the nuclear accumulation of Smad2 and/or Smad3, and the TGF-( beta)1 type I receptor (ALK-5) and its effectors mediate the epithelial to mesenchymal transition.
Role of Smad Proteins and Transcription Factor Sp1 in p21Waf1/Cip1 Regulation by Transforming Growth Factor-β*
- K. Pardali, A. Kurisaki, A. Morén, P. ten Dijke, D. Kardassis, A. Moustakas
- Biology, ChemistryThe Journal of Biological Chemistry
- 22 September 2000
Smad proteins play important roles in regulation of the p21 gene by TGF-β, and the functional cooperation of Smad proteins with Sp1 involves the physical interaction of these two types of transcription factors.
Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner.
- A. Kurisaki, S. Kose, Y. Yoneda, C. Heldin, A. Moustakas
- BiologyMolecular biology of the cell
- 1 April 2001
A pathway whereby Smad3 phosphorylation by the TGF-beta receptor leads to enhanced interaction with importin-beta1 and Ran-dependent import and release into the nucleus is described.
TGF-β type I receptor / ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
Although TGF-β acts as a tumor suppressor during early benign stages of skin tumourigenesis, it potently aggravates the malignancy at later stages, which occurs during transformation of squamous carcinoma to invasive spindle cell carcinoma.
Nuclear Factor YY1 Inhibits Transforming Growth Factor β- and Bone Morphogenetic Protein-Induced Cell Differentiation
YY1 represses Smad transcriptional activities in a gene-specific manner and thus regulates cell differentiation induced by TGF-β superfamily pathways.
The Mechanism of Nuclear Export of Smad3 Involves Exportin 4 and Ran
It is demonstrated that Smad3 is exported by a constitutive mechanism that is insensitive to leptomycin B and binds a conserved peptide sequence in the MH2 domain of Smad 3 in a Ran-dependent manner.
TIF1β regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner
- Yasuhiro Seki, A. Kurisaki, M. Asashima
- BiologyProceedings of the National Academy of Sciences
- 27 May 2010
The results suggest that TIF1β provides a phosphorylation-dependent, bidirectional platform for specific transcriptional factors and chromatin remodeling enzymes that regulate the cell differentiation process and the pluripotency of stem cells.
Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction.
Quartz-Seq2: a high-throughput single-cell RNA-sequencing method that effectively uses limited sequence reads
Improvements in the reaction steps make it possible to effectively convert initial reads to UMI counts, at a rate of 30–50%, and detect more genes in high-throughput single-cell RNA-seq methods.