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Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association.
The sudden increase in information derived from the completed Mycobacterium tuberculosis (Mtb) genome sequences has revealed the need for approaches capable of converting raw genome sequence dataExpand
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Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor
A fundamental challenge to the study of oxidative stress responses of Mycobacterium tuberculosis (Mtb) is to understand how the protective host molecules are sensed and relayed to control bacilliExpand
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Heme Oxygenase-1-derived Carbon Monoxide Induces the Mycobacterium tuberculosis Dormancy Regulon*
The mechanisms that allow Mycobacterium tuberculosis (Mtb) to persist in human tissue for decades and to then abruptly cause disease are not clearly understood. Regulatory elements thought to assistExpand
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Environmental heme-based sensor proteins: implications for understanding bacterial pathogenesis.
SIGNIFICANCE Heme is an important prosthetic group required in a wide array of functions, including respiration, photosynthesis, metabolism, O(2) transport, xenobiotic detoxification, and peroxideExpand
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ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis
Altered epigenetic reprogramming contributes to breast cancer progression and metastasis. How the epigenetic reader mediates breast cancer progression remains poorly understood. Here, we showed thatExpand
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Imaging the NADH:NAD+ Homeostasis for Understanding the Metabolic Response of Mycobacterium to Physiologically Relevant Stresses
The NADH:NAD+ ratio is the primary indicator of the metabolic state of bacteria. NAD(H) homeostasis is critical for Mycobacterium tuberculosis (Mtb) survival and is thus considered an important drugExpand
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The mechanism of redox sensing in Mycobacterium tuberculosis.
Tuberculosis epidemics have defied constraint despite the availability of effective treatment for the past half-century. Mycobacterium tuberculosis, the causative agent of TB, is continually exposedExpand
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Virulence factor SenX3 is the oxygen-controlled replication switch of Mycobacterium tuberculosis.
  • N. Singh, A. Kumar
  • Biology, Medicine
  • Antioxidants & redox signaling
  • 13 February 2015
AIM Morphogenetic switching between the replicating and nonreplicating states of Mycobacterium tuberculosis is regulated by oxygen, nitric oxide, and carbon monoxide levels. The mechanisms by whichExpand
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The extracellular matrix of mycobacterial biofilms: could we shorten the treatment of mycobacterial infections?
A number of non-tuberculous mycobacterium species are opportunistic pathogens and ubiquitously form biofilms. These infections are often recalcitrant to treatment and require therapy with multipleExpand
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Hydroalcoholic extract of Argyreia speciosa roots ameliorates HCl-mediated acute lung injury in mice
Objective: Argyreia speciosa is a popular Indian medicinal plant. It has long been used in the traditional Ayurvedic Indian medicine for various diseases. The present work was designed to evaluateExpand
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