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Mice Lacking Skeletal Muscle Actin Show Reduced Muscle Strength and Growth Deficits and Die during the Neonatal Period
TLDR
It is found that increases in cardiac and vascular smooth-muscle actin can partially compensate for the lack of skeletal actin in null mice, but this is not sufficient to support adequate skeletal muscle growth and/or function.
Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin.
TLDR
It is demonstrated that alterations in actin composition in the fetal and adult heart are associated with severe structural and functional perturbations.
Transgenic overexpression of cardiac actin in the mouse heart suggests coregulation of cardiac, skeletal and vascular actin expression
TLDR
In the presence of a small number of copies of the cardiac actin transgene, homeostatic mechanisms involved in maintaining actin levels are active and negatively regulate skeletal and vascularActin levels in the heart in response to increased expression of cardiac actIn.
, Deficits and Die during the Neonatal Period Reduced Muscle Strength and Growth Mice Lacking Skeletal Muscle Actin Show
TLDR
While increases in cardiac and vascular smooth-muscle actin can partially compensate for the lack of skeletal actin in null mice, this is not sufficient to support adequate skeletal muscle growth and/or function.