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Osteoprotection by semaphorin 3A
- M. Hayashi, T. Nakashima, M. Taniguchi, T. Kodama, A. Kumanogoh, H. Takayanagi
- Biology, Medicine
- 3 May 2012
The bony skeleton is maintained by local factors that regulate bone-forming osteoblasts and bone-resorbing osteoclasts, in addition to hormonal activity. Osteoprotegerin protects bone by inhibiting… Expand
FARP2 triggers signals for Sema3A-mediated axonal repulsion
Sema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the… Expand
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.
- K. Yoshida, T. Taga, +15 authors T. Kishimoto
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 9 January 1996
gp130 is a ubiquitously expressed signal-transducing receptor component shared by interleukin 6, interleukin 11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and… Expand
Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2
Semaphorins are a family of phylogenetically conserved soluble and transmembrane proteins. Although many soluble semaphorins deliver guidance cues to migrating axons during neuronal development, some… Expand
Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling
Cardiac chamber formation involves dynamic changes in myocardial organization, including trabeculation and expansion of the compact layer. The positional cues that regulate myocardial patterning,… Expand
Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin.
Semaphorins are axon guidance factors that assist growing axons in finding appropriate targets and forming synapses. Emerging evidence suggests that semaphorins are involved not only in embryonic… Expand
Semaphorins and their receptors in immune cell interactions
Semaphorins are newcomers to the growing panoply of immunoregulatory proteins. Members of this family were originally identified as proteins that provide axonal guidance cues during neuronal… Expand
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis
Semaphorins and their receptors have diverse functions in axon guidance, organogenesis, vascularization and/or angiogenesis, oncogenesis and regulation of immune responses. The primary receptors for… Expand
Structural basis for semaphorin signalling through the plexin receptor
Semaphorins and their receptor plexins constitute a pleiotropic cell-signalling system that is used in a wide variety of biological processes, and both protein families have been implicated in… Expand
Bimodal regulation of T cell-mediated immune responses by TIM-4.
- M. Mizui, Takashi Shikina, +5 authors H. Kikutani
- Medicine, Biology
- International immunology
- 1 May 2008
T cell Ig and mucin domain (TIM)-4 is preferentially expressed on antigen-presenting cells, and its counter-ligand, TIM-1, is thought to deliver co-stimulating signals to T cells. However, the… Expand