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ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells
TLDR
This review covers the current data on the mechanisms of ROS generation and existing antioxidant systems balancing the redox state in mammalian cells that can also be related to tumors.
Mitochondrial dysfunction and oxidative stress in aging and cancer
TLDR
This review focuses on the similarities between ageing-associated and cancer-associated oxidative stress and mitochondrial dysfunction as their common phenotype and suggests that the oxidative stress as a cause and/or consequence of the mitochondrial dysfunction is one of the main drivers of these processes.
Differential Expression of CHL1 Gene during Development of Major Human Cancers
TLDR
The role of CHL1 as a potentially novel specific biomarker in the early pathogenesis of two major histological types of renal cancer is supported and suggested that re-expression of the gene on the edge of tumor mass might promote local invasive growth and enable further metastatic spread in ovary, colon and breast cancer.
Important molecular genetic markers of colorectal cancer
TLDR
The present review discusses the most important and well-studied CRC biomarkers, and their potential clinical significance and current approaches to molecular classification of colorectal tumors.
A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock
TLDR
All stress factors but cold shock resulted in a decrease of lifespan proportional to the dose of treatment, however, stress-factors affected locomotor activity without correlation with lifespan.
Inactivation of the von Hippel-Lindau tumor suppressor leads to selective expression of a human endogenous retrovirus in kidney cancer
TLDR
Findings provide the first evidence that inactivation of a tumor suppressor gene can result in aberrant proviral expression in a human tumor and give insights needed for translational research aimed at boosting human immunity against antigenic components of this HERV-E.
Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays
TLDR
This study aimed to clarify genetic and epigenetic alterations that occur during lung carcinogenesis and to design perspective sets of newly identified biomarkers to allow early detection, tumor progression, metastases and to discriminate between SCC and ADC with sensitivity and specificity of 80–100%.
Hot spots of DNA double-strand breaks and genomic contacts of human rDNA units are involved in epigenetic regulation
TLDR
Mapping of hot spots of DSBs in a human 43-kb ribosomal DNA (rDNA) repeated unit suggests a strong link between chromosome breakage and several different mechanisms of epigenetic regulation of gene expression.
Molecular markers of paragangliomas/pheochromocytomas
TLDR
The present review contemplates the mutations associated with the development of pheochromocytomas/paragangliomas and their potential to serve as specific markers of these tumors and their progression.
Effect of lentivirus-mediated shRNA inactivation of HK1, HK2, and HK3 genes in colorectal cancer and melanoma cells
TLDR
It is demonstrated that simultaneous inactivation of HK1 and HK2 was sufficient to decrease proliferation and viability of melanoma and colorectal cancer cells and could be the key therapeutic targets for reducing aerobic glycolysis in examined cancers.
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