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Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus
The helix-loop-helix (HLH) protein NEUROD1 (also known as BETA2) functions as a regulatory switch for endocrine pancreatic development. In mice homozygous for a targeted disruption of Neurod,Expand
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Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study
Type 2 diabetes mellitus is characterised by resistance of peripheral tissues to insulin and a relative deficiency of insulin secretion. To find out which is the earliest or primary determinant ofExpand
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Physical activity and incidence of non-insulin-dependent diabetes mellitus in women
The potential role of physical activity in the primary prevention of non-insulin-dependent diabetes mellitus (NIDDM) is largely unknown. We examined the association between regular vigorous exerciseExpand
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Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents.
OBJECTIVE To determine whether insulin resistance or insulin deficiency is primary in the pathogenesis of type II diabetes. DESIGN Cohort analytic study of persons with normal glucose tolerance butExpand
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A prospective study of exercise and incidence of diabetes among US male physicians.
OBJECTIVE To examine prospectively the association between regular exercise and the subsequent development of non-insulin-dependent diabetes mellitus (NIDDM). DESIGN Prospective cohort studyExpand
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Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease*
Because of its availability, ease of collection, and correlation with physiology and pathology, urine is an attractive source for clinical proteomics/peptidomics. However, the lack of comparable dataExpand
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Microalbuminuria and the risk for early progressive renal function decline in type 1 diabetes.
This study aimed to establish the time of initiation and the determinants of renal function decline in type 1 diabetes. Until now, such decline has been assumed to be a late-occurring eventExpand
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Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes.
Levels of proinflammatory cytokines associate with risk for developing type 2 diabetes but whether chronic inflammation contributes to the development of diabetic complications, such as ESRD, isExpand
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Predisposition to hypertension and susceptibility to renal disease in insulin-dependent diabetes mellitus.
Only one third of patients with juvenile-onset insulin-dependent diabetes seem to be susceptible to diabetic nephropathy. To test whether this susceptibility is related to a predisposition toExpand
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Epidemiologic approach to the etiology of type I diabetes mellitus and its complications.
DIABETES arises through two etiologically distinct routes.1 Type I diabetes is the result of immunologically mediated destruction of the pancreatic beta cells, and usually requires replacement ther...
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