• Publications
  • Influence
CpG motifs in bacterial DNA and their immune effects.
  • A. Krieg
  • Biology
    Annual review of immunology
  • 2002
TLDR
Oligodeoxynucleotides containing CpG ODN enhance the development of acquired immune responses for prophylactic and therapeutic vaccination and protect against lethal challenge with a wide variety of pathogens.
CpG motifs in bacterial DNA trigger direct B-cell activation
TLDR
The potent immune activation by CpG oligon nucleotides has impli-cations for the design and interpretation of studies using 'antisense' oligonucleotides and points to possible new applications as adjuvants.
Therapeutic potential of Toll-like receptor 9 activation
  • A. Krieg
  • Biology, Medicine
    Nature Reviews Drug Discovery
  • 1 June 2006
TLDR
An overview of the preclinical data and early human clinical trial results using synthetic oligodeoxynucleotides (ODN) as TLR9 agonists to improve vaccines and treat cancer, infectious disease and allergy/asthma is provided.
CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.
TLDR
Stimulatory CpG DNA motifs induced B, T, and natural killer cells to secrete cytokine more effectively than did lipopolysaccharide, suggesting immune recognition of bacterial DNA may contribute to the cytokine, as well as the antibody production characteristic of an innate inflammatory response.
Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities
TLDR
C‐ class ODN may represent new therapeutic drugs that combine the effects of A‐ and B‐Class ODN for broad applications in infectious disease or cancer therapy, and in vivo studies demonstrate that C‐ Class ODN are very potent Th1adjuvants.
Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells.
TLDR
It is demonstrated that particular CpG ODN sequences exist which, due to high IFN-alpha/beta induction in PDC, induce a set of immune responses typical for viral infection.
Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells1
TLDR
The structure of a highly active human CpG motif is defined and its molecular mechanism of action in primary human B cells is characterized.
CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity
TLDR
CpG ODN provide a signal to switch on Th1-dominated responses to coadministered antigen and are potential adjuvants for human vaccines to elicit protective Th1 immunity.
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