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Cytokine-induced human IFN-gamma-secreting effector-memory Th cells in chronic autoimmune inflammation.
T-helper (Th) cells activated by cytokines in the absence of T-cell receptor ligation are suspected to participate in inflammatory processes by production of interferon-gamma (IFN-gamma). Still, theExpand
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Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib.
Imatinib mesylate is a selective inhibitor of a few tyrosine kinases including KIT, and it is the first effective treatment for gastrointestinal stromal tumors (GISTs). We monitored the serum levelsExpand
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Cytokines derived from alveolar macrophages induce fever after bronchoscopy and bronchoalveolar lavage
As much as one-third of patients develop fever and flu-like symptoms after fiberoptic bronchoscopy (FOB) and bronchoalveolar lavage (BAL) for yet unknown reasons. The aim of the present study was toExpand
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Expression of the CD2 Activation Epitope T11‐3 (CD2R) on T Cells in Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis, Systemic Lupus Erythematosus, Ankylosing Spondylitis, and Lyme Disease:
CD2R is an activation‐associated epitope unmasked by a conformational change of the CD2 cell‐surface glycoprotein. In spite of elaborate studies on the role of CD2 and CD2R in adhesion andExpand
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Growth factor signalling in clinical breast cancer and its impact on response to conventional therapies: the Edinburgh experience.
Neoadjuvant endocrine treatment in which therapy is given while the primary tumour is still in the breast provides a highly useful model system by which to identify mechanisms associated with de novoExpand
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Pharmacokinetic/Pharmacodynamic Modelling of Receptor Internalization with CRTH2 Antagonists to Optimize Dose Selection
Background and ObjectiveThe chemoattractant receptor-homologous molecule expressed on T helper-2 cells (CRTH2) is a G-protein-coupled receptor for prostaglandin D2 (PGD2), a key mediator inExpand
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Modeling the Effect of the Selective S1P1 Receptor Modulator Ponesimod on Subsets of Blood Lymphocytes
PurposeThis analysis aimed at describing the effect of the selective sphingosine-1-phosphate receptor 1 modulator ponesimod on lymphocyte subsets in peripheral blood. As the involvement of differentExpand
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CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice
Although rare, CALM/AF10 is a chromosomal rearrangement found in immature T-cell acute lymphoblastic leukemia (T-ALL), acute myeloid leukemia, and mixed phenotype acute leukemia of T/myeloid lineagesExpand