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Resorcinolic Lipids, the Natural Non-isoprenoid Phenolic Amphiphiles and Their Biological Activity.
The biogenetic pathway of these compounds, described in textbooks and recent reviews, is based on incomplete experimental data supplemented with chemical considerations, which suggests their less important role in cellular physiology and biochemistry. Expand
Cereal alkylresorcinols elevate gamma-tocopherol levels in rats and inhibit gamma-tocopherol metabolism in vitro.
High levels of dietary AR moderately affect gamma-tocopherol, possibly via inhibition of tocopherol metabolism, and decrease liver cholesterol in rats, indicating that they can accumulate in the fatty tissues of rats. Expand
Alkylresorcinols in selected Polish rye and wheat cereals and whole-grain cereal products.
This work not only provides a detailed examination of alkylresorcinols in selected Polish rye and wheat cultivars and selected whole-grain cereal products, but also demonstrates that this type of analysis accompanied by the use of proper statistical algorithms offers an objective way to evaluate the quality of whole- grain rye and/or wheat and their derived products. Expand
Biological activity of phenolic lipids
The ability of these compounds to inhibit bacterial, fungal, protozoan and parasite growth seems to depend on their interaction with proteins and/or on their membrane-disturbing properties. Expand
Higher cardol homologs (5-alkylresorcinols) in rye seedlings.
The relatively high level of alkylresorcinols in mitochondria and plastids suggests that their synthetic pathway and/or biological function may be related to these cellular compartments. Expand
Cereal Alkylresorcinols Elevate γ-Tocopherol Levels in Rats and Inhibit γ-Tocopherol Metabolism In Vitro
Alkylresorcinols were detected in the perirenal adipose tissue samples of rats fed AR, indicating that they can accumulate in the fatty tissues of rats, and may increase gamma-tocopherol levels via inhibition of tocopherol metabolism in vivo. Expand
Does isoprene protect plant membranes from thermal shock? A molecular dynamics study.
Direct evidence is provided for the first time direct evidence that isoprene stabilizes lipid membranes and reduces the likelihood of a phospholipid membrane undergoing a heat induced phase transition. Expand
The encapsulation of idarubicin within liposomes using the novel EDTA ion gradient method ensures improved drug retention in vitro and in vivo.
The presented results fully demonstrate the superiority of the proposed method of idarubicin encapsulation over existing methods, which offers the possibility of encapsulating not only all the anthracyclines, but also other weakly amphiphilic bases within the liposomes. Expand
Cereal grain resorcinolic lipids inhibit H2O2-induced peroxidation of biological membranes.
The results obtained show that alkylresorcinols should be recognized as hydrophobic, membrane-localised antioxidants. Expand
Natural amphiphilic phenols as bioactive compounds
What kind of phenolic lipids? The phenolic lipids are a large group of natural compounds, biogenetically derived from the polyacetate pathway, i.e. they are non-isoprenoic compounds. In general, thisExpand