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Influence of arterial oxygen tension on coronary vasodilator action of nitroglycerine.
In 11 anesthetized open-chest dogs, controlled perfusion of the left circumflex coronary artery was accomplished by shunting blood from the femoral artery and vein via a peristaltic pump by changing the proportion of arterial and venous blood reaching the inflow side of the pump.
GYKI-12 743, a novel antihypertensive compound with special alpha-adrenergic blocking profile.
The electrophysiological effects of unilateral MCA occlusion for 45 minutes and subsequent recirculation for 3 hours were studied in cats and it was concluded that entry of the orbita results in significant and long lasting changes of the EEG, so, a less traumatic method of focal ischemia should be elaborated.
Thrombin inhibitor (GYKI-14766) prevente thrombin induced vascular effects
New dihydropyridine compound (GYKI-46 544) with bradycardiac and vasodilatory effects.
Study off GYKI-46.544, a new bradycardizing calcium antagonist in isolated cardiovascular preparations
Electrophysiological effects of rosiglitazone on heart ventricular papillary muscles of control and diabetic histidine decarboxylase knock-out and wild-type mice
Rosiglitazone is a high affinity ligand for the peroxisome proliferator-activated receptor gamma which is responsible for the insulin-sensitizing action of the compound.
[Ventricullar fibrillation in the acute stage of myocardial infarct. II. The characteristics of the heart functional changes in experimental myocardial infarct complicated by ventricullar…
In acute experiments on dogs, occlusion of the anterior descending branch of the left coronary artery induced two-phase changes in the cardiac and stroke output, drop in arterial pressure, and decrease in the rate of cardiac contractions.
[Antifibrillatory activity of propranolol in experimental myocardial infarct and its cardiodepressive and hypotensive action].
It is shown that it is possible in principle to preserve the antifibrillation activity of propranolol infused intravenously in a dose of 1mg/kg for correcting its cardiodepressive and hypotensive effect in combined intravenous infusion of 0.02 mg/kg corglycon.
Vascular and cardiac electrophysiological activity of GYKI-12 743 in isolated tissue preparations.
Possibilities of pharmacological prevention of thrombin-induced coronary vasospasm.