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Electrophysiological effects of EGIS-7229, a new antiarrhythmic agent, in isolated mammalian and human cardiac tissues
Abstract The cellular electrophysiological effects of EGIS-7229 (5-chlor-4-[N-(3,4-dimethoxy-phenyl-ethyl)-amino-propylamino]-3(2H)-pyridazinone fumarate), a novel antiarrhythmic agent, was studiedExpand
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Comparative study on cardiotoxic effect of Tinuvin 770: a light stabilizer of medical plastics in rat model.
Tinuvin 770 [bis(2,2,6,6-tetramethyl-4-piperidinyl) sebacate], is a UV light stabilizer plastic additive used worldwide. It is a component of many plastic materials used in medical and foodExpand
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Silymarin and Vitamin E do not Attenuate and Vitamin E Might Even Enhance the Antiarrhythmic Activity of Amiodarone in a Rat Reperfusion Arrhythmia Model
Oxidative stress and lysosomal phospholipoidosis, which also might be partly attributed to free radicals induced by amiodarone (AM), may be involved in AM toxicity, which can be prevented byExpand
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A light stabilizer Tinuvin 770-induced toxic injury of adult rat cardiac myocytes.
Tinuvin 770/bis(2,2,6,6-tetramethyl-4-piperidinyl)sebacate is a worldwide used light stabilizer for plastic materials like polyolefins. Tinuvin 770 is a biologically active component of polypropyleneExpand
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Vasoconstrictor 5-HT receptors in the smooth muscle of the rat middle cerebral artery.
Serotonin (5-HT) can constrict cerebral arteries via activation of 5-HT(1B) and 5-HT(2A) receptors. Our goal was to reveal the importance and relative contribution of the two 5-HT receptor subtypesExpand
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Effects of EGIS-7625, a Selective and Competitive 5-HT2B Receptor Antagonist
Our aim was to specify the 5-HT2 subtype selectivity of EGIS-7625 (1-benzyl-4-[(2-nitro-4-methyl-5-amino)-phenyl]-piperazine), a new 5-HT2B ligand, in receptor binding studies and characterize itsExpand
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Detection of tinuvin 770, a light stabilizer of plastic materials from dialysis membranes, by high-performance liquid chromatographic analysis.
Tinuvin 770 [bis(2,2,6,6-tetramethyl-4-piperidinyl)sebacate] is a pharmacologically active agent used worldwide as a light stabilizer for plastic materials. In vitro studies show that it is an L-typeExpand
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Effects of the antiarrhythmic agent EGIS-7229 (S 21407) on calcium and potassium currents in canine ventricular cardiomyocytes
Abstract. Based on earlier pharmacological studies performed using conventional microelectrodes EGIS-7229 (S 21407), the novel antiarrhythmic candidate, was suggested to have a combined mode ofExpand
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Effects of dofetilide and EGIS-7229, an antiarrhythmic agent possessing class III, IV, and IB activities, on myocardial refractoriness in hyperkalemia, hypokalemia, and during beta-adrenergic
Lengthening of the effective refractory period (ERP) by EGIS-7229, a class III/Ib/IV drug, and by dofetilide, a selective I(Kr) blocker, was compared in normokalemia (NK), hypokalemia (LK), andExpand
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Decreased vasoconstrictor responses in remote cerebral arteries after focal brain ischemia and reperfusion in the rat, in vitro.
The effects of brain ischemia and reperfusion on smooth muscle function in remote cerebral and peripheral arteries are hardly known. Maximum vasoconstrictions (E(max)) caused by 120mmol/l KCl andExpand
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