• Publications
  • Influence
Regulation of cytotoxic T cells by ecto-nicotinamide adenine dinucleotide (NAD) correlates with cell surface GPI-anchored/arginine ADP-ribosyltransferase.
This report demonstrates that incubation of cytotoxic T cells with NAD causes suppression of their ability to proliferate in response to stimulator cells or to lyse targets. Effects are evident afterExpand
  • 102
  • 6
A short history of cGMP, guanylyl cyclases, and cGMP-dependent protein kinases.
Here, we review the early studies on cGMP, guanylyl cyclases, and cGMP-dependent protein kinases to facilitate understanding of development of this exciting but complex field of research encompassingExpand
  • 62
  • 6
  • PDF
Role of soluble guanylyl cyclase-cyclic GMP signaling in tumor cell proliferation.
Our previous studies demonstrate a differential expression of nitric oxide (NO) signaling components in ES cells and our recent study demonstrated an enhanced differentiation of ES cells intoExpand
  • 45
  • 6
Developments in active noise control sound systems for magnetic resonance imaging
Abstract Magnetic resonance imaging (MRI) scanners can produce noise measuring over 130 dB SPL. This noise stimulates the auditory nervous system, limiting the dynamic range for stimulus drivenExpand
  • 44
  • 4
  • PDF
Differential expression of genes involved in cGMP-dependent nitric oxide signaling in murine embryonic stem (ES) cells and ES cell-derived cardiomyocytes.
Nitric oxide (NO) performs multiple physiological roles as a biological signaling molecule. The role of NO and cGMP signaling in embryonic stem (ES) cell-derived cardiomyocytes (CM) has beenExpand
  • 52
  • 3
Role of nitric oxide signaling components in differentiation of embryonic stem cells into myocardial cells
Nitric oxide (NO) is involved in number of physiological and pathological events. Our previous studies demonstrated a differential expression of NO signaling components in mouse and human ES cells.Expand
  • 84
  • 2
  • PDF
A constitutively activated mutant of human soluble guanylyl cyclase (sGC): Implication for the mechanism of sGC activation
Heterodimeric αβ soluble guanylyl cyclase (sGC) is a recognized receptor for nitric oxide (NO) and mediates many of its physiological functions. Although it has been clear that the heme moietyExpand
  • 56
  • 2
  • PDF
Restoring Soluble Guanylyl Cyclase Expression and Function Blocks the Aggressive Course of Glioma
The NO and cGMP signaling pathways are of broad physiological and pathological significance. We compared the NO/soluble guanylyl cyclase (sGC)/cGMP pathway in human glioma tissues and cell lines withExpand
  • 18
  • 2
  • PDF
Nitric oxide and cyclic GMP signaling pathway as a focus for drug development.
Recent progress in understanding of the nitric oxide and cGMP signaling pathway provided evidence for mechanism of action of known drugs and identified novel targets for drug development. TheseExpand
  • 26
  • 2
Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination
Summary The nitric oxide (NO)-cyclic GMP pathway contributes to human stem cell differentiation, but NO free radical production can also damage DNA, necessitating a robust DNA damage response (DDR)Expand
  • 13
  • 2