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In Vitro Metabolism Studies of Polybrominated Diphenyl Ethers Using Rat and Human Liver Microsomes
A number of studies have recently reported the bioaccumulation of the commonly used fire retardants, Polybrominated Diphenyl Ethers (PBDEs), in humans and wildlife. Exposure of animals to PBDEs has
Evaluation of surfactants as solubilizing agents in microsomal metabolism reactions with lipophilic substrates
TLDR
Of the surfactants investigated, Cremophor EL and Tween 80 displayed the best combination of increased BDE-100 solubility and minimal inhibition of microsomal metabolism, however, a comparison of the in vitro metabolism products of Bde-100 in the presence of the two surfactant revealed varying amounts of metabolites depending on the surfacts used.
2,3-Bifunctionalized Quinoxalines: Synthesis, DNA Interactions and Evaluation of Anticancer, Anti-tuberculosis and Antifungal Activity
A variety of 2,3-bifunctionalized quinoxalines (6-14) have been prepared by the condensation of 1,6-disubstituted-hexan-1,3,4,6-tetraones (1-4) with o-phenylenediamine, (R,R)-1,2-diaminocyclohexane
Reaction of alkylcobalamins with thiols.
TLDR
Because the authors have been unable to detect trans coordination of 2-mercaptoethanol, they favor a mechanism that involves a hydride attack on the Co-methylene carbon of (carboxymethyl)cobalamin rather than a trans attack of the thiol on the cobalt atom.
Synthesis and Structure of Bis(pi-cyclopentadienyl)vanadium(IV) 1,10-Phenanthroline and 2,2'-Bipyridine Compounds and Their Interactions with Artificial Membranes.
TLDR
It is shown that the ability of metallocenes to enhance the permeability of a liposomal membrane depends on the hydrophobicity, as well as the size and planarity of the ancillary chelated ligands, but not the nature of the central metal ion.
Dynamics of hydride transfer between NAD+ analogs
Transfert d'hydrure entre la (dihydro-9,10 methyl-10)acridine et le (benzo-1 cyano-3)quinoleinium dans 15 solvants differents
Interactions of Vanadocene(IV)-Chelated Complexes with Artificial Membranes
The membrane interactions of five vanadocene(IV)-chelated complexes, which are very effective spermicidal agents, have been studied using zwitterionic and negative unilamellar liposomes. In
Novel Cytotoxic Oxopyridoindolizines: iso-Propyl-7,8,9-tri-chloro-6,7,8,9-tetrahydro-5-oxopyrido[2,3-a]-indolizine-10-carboxylates (OPIC)
A series of eight new alkyl-7,8,9-trichloro-6,7,8,9-tetrahydro-5-oxopyrido[2,3-a]-indolizine-10-carboxylates (OPIC), analogues of camptothecin (CPT), were prepared in a one-pot reaction of
Induction of aerobic peroxidation of liposomal membranes by bis(cyclopentadienyl)-vanadium(IV) (acetylacetonate) complexes.
TLDR
A comparison of the rates of the lipid peroxidation reaction demonstrated that the electron-donating capacity of the substituted acetylacetonate ligand significantly influences the rate of reaction.
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