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Overlapping expression patterns and redundant roles for AP‐2 transcription factors in the developing mammalian retina
Background: We have previously shown that the transcription factor AP‐2α (Tcfap2a) is expressed in postmitotic developing amacrine cells in the mouse retina. Although retina‐specific deletion ofExpand
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RhoA/ROCK Signaling Regulates TGFβ-Induced Epithelial-Mesenchymal Transition of Lens Epithelial Cells through MRTF-A
Transforming growth factor (TGF)-β-induced epithelial-mesenchymal transition (EMT) leads to the formation of ocular fibrotic pathologies, such as anterior subcapsular cataract and posterior capsuleExpand
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Matrix metalloproteinase-9-null mice are resistant to TGF-β-induced anterior subcapsular cataract formation.
Epithelial-mesenchymal transition (EMT) is associated with fibrotic diseases in the lens, such as anterior subcapsular cataract (ASC) formation. Often mediated by transforming growth factor (TGF)-β,Expand
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Dual function of TGFβ in lens epithelial cell fate: implications for secondary cataract
TGFβ signaling is linked to posterior capsule opacification (PCO), the most common complication of cataract surgery. TGFβ can induce primary lens epithelial cells to differentiate into two disparate,Expand
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Nuclear translocation of myocardin-related transcription factor-A during transforming growth factor beta–induced epithelial to mesenchymal transition of lens epithelial cells
Purpose Transforming growth factor beta (TGFβ) is a known inducer of epithelial to mesenchymal transition (EMT), and studies in other systems have shown that nuclear localization of theExpand
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β-Catenin/CBP–Dependent Signaling Regulates TGF-β–Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells
Purpose Transforming growth factor-β–induced epithelial–mesenchymal transition (EMT) is one of the main causes of posterior capsular opacification (PCO) or secondary cataract; however, the signalingExpand
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Serous pigment epithelium detachment associated with age-related macular degeneration: a possible treatment approach.
To evaluate the effects of intravitreal triamcinolone acetonide (TA) as a monotherapy of serous Pigment Epithelial Detachment (PED) associated with AMD (Age-Related Macular Degeneration), this studyExpand
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The Lens Capsule: Synthesis, Remodeling, and MMPs
The lens capsule is an amorphous, elastic structure that encapsulates the ocular lens. It is secreted by cells of the lens and is composed primarily of type IV collagen and laminin along withExpand
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