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Randomized controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for the eradication of methicillin-resistant Staphylococcus
Treatment with topical mupirocin, chlorhexidine gluconate washes, oral rifampin, and doxycycline for 7 days was safe and effective in eradicating MRSA colonization in hospitalized patients for at least 3 months.
Insights into Diabetic Kidney Disease Using Urinary Proteomics and Bioinformatics.
The findings suggest that there is a spectrum of biological processes in the diabetic kidney and that assessing protein networks may be more informative than individual markers with respect to the stage of disease and the risk of progression.
Utility of HLA Antibody Testing in Kidney Transplantation.
The technical aspects of single antigen bead assays are discussed, their quantitative limitations are emphasized, and the utility of HLA antibody testing in identifying and managing important pre- and post-transplant clinical outcomes are explored.
Loss of ACE2 Exacerbates Murine Renal Ischemia-Reperfusion Injury
Data demonstrate a protective effect of ACE2 in I/R AKI, which is associated with increased neutrophil, macrophage, and T cell infiltration in the kidney and changes in inflammatory cell infiltrates and cytokine expression associated with greater apoptosis and oxidative stress.
Peptidomic Analysis of Urine from Youths with Early Type 1 Diabetes Reveals Novel Bioactivity of Uromodulin Peptides In Vitro*
A urinary signature of uromodulin peptides associated with early type 1 diabetes before clinical manifestations of kidney disease is identified and novel bioactivity of two peptides in vitro is demonstrated in vitro using NFκB luciferase activity and neutrophil chemotaxis assays.
Searching for new biomarkers of renal diseases through proteomics.
It is clear that the field of proteomics has not yet fulfilled its promise, but ongoing efforts to standardize sample collection and preparation, improve study designs, perform multicenter validations, and create joint industry-regulatory bodies offer promise for the recognition of novel molecules that could change clinical nephrology forever.
Extracellular Matrix Injury of Kidney Allografts in Antibody-Mediated Rejection: A Proteomics Study.
Proteomic analysis performed on laser-captured and microdissected glomeruli and tubulointerstitium identified early ECM remodeling, which may represent a new therapeutic opportunity in chronic AMR.