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Acquisition of resistance to cisplatin is accompanied by changes in the cellular pharmacology of copper.
Impaired uptake of cisplatin (DDP) consistently accompanies the acquisition of resistance to the platinum drugs. The pathways by which DDP enters or exits from cells remain poorly defined. UsingExpand
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Identification of genes that mediate sensitivity to cisplatin.
Cisplatin (cDDP) is effective against some human tumors, but many are intrinsically resistant and, even among initially sensitive tumors, acquired resistance develops commonly during treatment. ItExpand
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Possible Anti-tumor Promoting Properties of Edible Plants from Thailand, and Identification of an Active Constituent, Cardamonin, of Boesenbergia pandurata
Possible anti-tumor promoting properties of a total of 40 methanol extracts from Thai edible plants, including 5 non-edible species, were estimated in vitro by an inhibition test of tumorExpand
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Hypoxia-induced enrichment and mutagenesis of cells that have lost DNA mismatch repair.
Loss of DNA mismatch repair (MMR) increases the risk of spontaneous mutations. We sought to determine whether there was an interaction between hypoxia and MMR deficiency that might contribute to theExpand
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Efflux pump inhibitors reduce the invasiveness of Pseudomonas aeruginosa.
Efflux systems are thought to contribute to antimicrobial resistance in Pseudomonas aeruginosa. The mexAB-oprM deletion strain of P. aeruginosa PAO1 is compromised in its capacity to invadeExpand
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Analysis of Peach Tree Damage Caused by Peach Silver Mite, Aculus fockeui (Nalepa et Trouessart) (Acari: Eriophyidae).
モモサビダニによるモモの葉の被害が光合成速度,果実品質,落葉および樹勢に及ぼす影響について検討した.1. 被害葉では健全葉に比べ光合成速度が著しく低下した.収穫期(8月下旬)の葉の被害度と果実の重量,酸度との間には有意な相関関係がみられなかったが,糖度は葉の被害度が増加するにつれて有意に減少した.また,9月下旬の落葉率は収穫期の葉の被害度が増加するにつれて有意に増加した.2.Expand
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P53 modulates the effect of loss of DNA mismatch repair on the sensitivity of human colon cancer cells to the cytotoxic and mutagenic effects of cisplatin.
This study examined how the DNA mismatch repair (MMR) system and p53 interact to maintain genomic integrity in the presence of the mutagenic stress induced by cisplatin (DDP). Sensitivity to theExpand
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Pathology of the peripheral nerve in the twitcher mouse following bone marrow transplantation
The peripheral nerve of the homozygous twitcher mouse (twi/twi), a murine model of globoid cell leukodystrophy (GLD), was examined following bone marrow transplantation (BMT). The light and electronExpand
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Suppression of the Deformation of Raji Cells by (E)-2-Alkenals, Aroma Components of Coriander (Coriandrum Sativum L.) Leaves, and Behavior of (E)-2-Dodecenal in Rat Blood
(E)-2-alkenals (C10-C16), isolated from coriander (Coriandrum sativum L.) leaves, were found to be a chemopreventive agent for deformation of Raji cells carrying the genome of Epstein-Barr virusExpand
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