A. Komaroff

Publications873
h-index57
Citations17,251
Highly Influential Citations1,013
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The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
We have developed a conceptual framework and a set of research guidelines for use in studies of the chronic fatigue syndrome. The guidelines cover the clinical and laboratory evaluation of persons… Expand
The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group.
TLDR
This work proposes a conceptual framework and a set of guidelines that provide a comprehensive, systematic, and integrated approach to the evaluation, classification, and study of persons with this condition and other fatiguing illnesses. Expand
Chronic fatigue syndrome: a working case definition.
TLDR
A new name is proposed for the chronic Epstein-Barr virus syndrome--the chronic fatigue syndrome--that more accurately describes this symptom complex as a syndrome of unknown cause characterized primarily by chronic fatigue. Expand
Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors
TLDR
The gag and env sequences from CFS patients were more closely related to those of polytropic mouse endogenous retroviruses than to those that of XMRVs and were even less closely related than those of ecotropic MLVs, which is a genetically diverse group of MLV-related viruses. Expand
The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro
TLDR
The data suggest that HHV-6 is unique among human herpesviruses: it specifically and efficiently integrates into telomeres of chromosomes during latency rather than forming episomes, and the integrated viral genome is capable of producing virions. Expand
Prevalence of fatigue and chronic fatigue syndrome in a primary care practice.
TLDR
While chronic, debilitating fatigue is common in medical outpatients, CFS is relatively uncommon and depends substantially on the case definition used. Expand
Health status in patients with chronic fatigue syndrome and in general population and disease comparison groups.
TLDR
Patients with CFS had marked impairment, in comparison with the general population and disease comparison groups, and the degree and pattern of impairment was different from that seen in patients with depression. Expand
Chronic Fatigue and the Chronic Fatigue Syndrome: Prevalence in a Pacific Northwest Health Care System
TLDR
The results of the first study of the chronic fatigue syndrome in the community are reported, which surveyed 4000 members of a large health maintenance organization and compared the results of systematic physical and laboratory examinations and assessments of psychological distress and functional status in persons with chronic fatigue. Expand
Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus.
An independent strain (JI) of human herpesvirus 7 (HHV-7) was isolated from a patient with chronic fatigue syndrome (CFS). No significant association could be established by seroepidemiology between… Expand
A randomized trial of a computer-based intervention to reduce utilization of redundant laboratory tests.
TLDR
Reminders about orders for apparently redundant laboratory tests were effective when delivered, however, the overall effect was limited because many tests were performed without corresponding computer orders, and many orders were not screened for redundancy. Expand
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