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Simple mechanochemistry describes the dynamics of kinesin molecules
The simplest (N = 2)-state model with fixed load-distribution factors and kinetic rate constants concordant with stopped-flow experiments, accounts for the global (V, F, L, [ATP]) interdependence and, further, matches relative acceleration observed under assisting loads.
Molecular motors: a theorist's perspective.
This review focuses on discrete kinetic and stochastic models that yield predictions for the mean velocity, V(F, [ATP], ...), and other observables as a function of an imposed load force F, the ATP concentration, and other variables.
Phase diagram of one-dimensional driven lattice gases with open boundaries
We consider the asymmetric simple exclusion process (ASEP) with open boundaries and other driven stochastic lattice gases of particles entering, hopping and leaving a one- dimensional lattice. The
ATP hydrolysis stimulates large length fluctuations in single actin filaments.
Polymerization dynamics of single actin filaments is investigated theoretically using a stochastic model that takes into account the hydrolysis of ATP-actin subunits, the geometry of actin filament
Asymmetric simple exclusion model with local inhomogeneity
We study a totally asymmetric simple exclusion model with open boundary conditions and a local inhomogeneity in the bulk. It consists of a one-dimensional lattice with particles hopping
Single-molecule analysis of DNA-protein complexes using nanopores
This work presents a method for rapid measurement of DNA-protein interactions using voltage-driven threading of single DNA molecules through a protein nanopore, which reveals energy barriers affecting complex dissociation.
The force exerted by a molecular motor.
An elementary "barometric" relation for the driving force is introduced that applies to a range of kinetic and stochastic models and satisfies an Einstein-type relation in terms of the velocity and diffusion coefficient of the (load-free) motor.