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The perivascular niche regulates breast tumor dormancy
TLDR
It is revealed that stable microvasculature constitutes a dormant niche, whereas sprouting neovasculature sparks micrometastatic outgrowth, which is a surprising result in dormancy models and in zebrafish.
ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function*
TLDR
It is shown that ChChd3 is a scaffolding protein that stabilizes protein complexes involved in maintaining crista architecture and protein import and is thus essential for maintaining mitochondrial structure and function.
Import of peroxisomal matrix and membrane proteins.
TLDR
The principal areas of progress are the identification of new peroxins, definition of protein-protein interactions among peroxin leading to the recognition of complexes involved in peroxisomal protein import, insight into the biogenesis ofperoxisome membrane proteins, and, of most importance, the elucidation of the role of many conservedperoxins in human disease.
Proteomics gives insight into the regulatory function of chloroplast thioredoxins
Thioredoxins are small multifunctional redox active proteins widely if not universally distributed among living organisms. In chloroplasts, two types of thioredoxins (f and m) coexist and play
The Peroxin Pex19p Interacts with Multiple, Integral Membrane Proteins at the Peroxisomal Membrane
TLDR
Coimmunoprecipitation of Pex19p from fractions that contain peroxisomes or cytosol revealed that the interactions between predominantly cytosolic P Ex19p and the iPMPs occur in the organelle pellet that contains peroxISomes, suggesting that PEx19p may have a chaperone-like role at the peroxIsome membrane and that it is not the receptor for targeting of iPMP sequences to theperoxisome.
Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake.
TLDR
TAT1 and TAT2 encode novel members of the yeast amino acid permease family composed of integral membrane proteins that share 30 to 40% identity, indicating that the inhibition of amino acid transport by the drug is posttranscriptional.
Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae
TLDR
The mRNA and protein expression in Saccharomyces cerevisiae cultured in rich or minimal media was analyzed by oligonucleotide arrays and quantitative multidimensional protein identification technology and a clustering approach based on protein pathways and protein complexes was implemented.
A Novel Link between Fic (Filamentation Induced by cAMP)-mediated Adenylylation/AMPylation and the Unfolded Protein Response*
TLDR
It is demonstrated that HYPE localizes to the lumen of the endoplasmic reticulum via its hydrophobic N terminus and adenylylates the ER molecular chaperone, BiP, at Ser-365 and Thr-366, and enhances BiP's ATPase activity, which is required for refolding misfolded proteins while coping with ER stress.
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