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Noncanonical Autophagy Promotes the Visual Cycle
TLDR
It is established that the interplay of phagocytosis and autophagy within the RPE is required for both POS degradation and the maintenance of retinoid levels to support vision. Expand
Noncanonical Autophagy Promotes the Visual Cycle
Ji-Young Kim,1,5 Hui Zhao,1,5 Jennifer Martinez,2 Teresa Ann Doggett,1 Alexander V. Kolesnikov,1 Peter H. Tang,3 Zsolt Ablonczy,3 Chi-Chao Chan,4 Zhenqing Zhou,1 Douglas R. Green,2,* and Thomas A.Expand
Age-Related Deterioration of Rod Vision in Mice
TLDR
The results argue against age-related deficiency of 11-cis-retinal in the B6D2F1/J mouse rod visual cycle and Surprisingly, the level of cellular dark noise was increased in aged rods, providing an alternative mechanism for their desensitization. Expand
Reprogramming of adult rod photoreceptors prevents retinal degeneration
TLDR
It is hypothesized that converting adult rods into cones, via knockdown of the rod photoreceptor determinant Nrl, could make the cells resistant to the effects of mutations in rod-specific genes, thereby preventing secondary cone loss. Expand
Ex vivo ERG analysis of photoreceptors using an in vivo ERG system
TLDR
The ex vivo ERG adapter provides a simple and affordable alternative to designing a custom-built transretinal recordings setup for the study of photoreceptors and provides a roadmap to the rigorous quantitative analysis of rod and cone responses made possible with such a system. Expand
G-Protein βγ-Complex Is Crucial for Efficient Signal Amplification in Vision
TLDR
It is demonstrated that transducin βγ-complex controls signal amplification of the rod phototransduction cascade and is critical for the ability of rod photoreceptors to function in low light conditions. Expand
Novel functional activities of anti-dna autoantibodies from sera of patients with lymphoproliferative and autoimmune diseases
TLDR
Results were obtained that indicate the complement-independent cytotoxicity of anti-DNA autoantibodies isolated from blood of patients with SLE and chronic lymphocytic leukemia and a new mechanism of formation of DNA-specific catalytic Abs has been proposed based on the increased crossreactivity of polyclonal DNA-abzymes to DNA-depleted nuclear matrix proteins. Expand
The DEP Domain Determines Subcellular Targeting of the GTPase Activating Protein RGS9 In Vivo
TLDR
It is reported that the DEP domain of a photoreceptor-specific signaling protein, R GS9, plays an essential role in RGS9 delivery to the intracellular compartment of its functioning, the rod outer segment, and indicates that a novel function of the DEPs is to target a signaling protein to a specific compartment of a highly polarized neuron. Expand
The Mammalian Cone Visual Cycle Promotes Rapid M/L-Cone Pigment Regeneration Independently of the Interphotoreceptor Retinoid-Binding Protein
TLDR
It is concluded that the retina visual cycle is critical for the initial rapid regeneration of mouse M/L-cone pigment during dark adaptation, whereas the slower RPEVisual cycle is required to complete the process. Expand
Anti-DNA autoantibodies reveal toxicity to tumor cell lines.
TLDR
It was shown that treatment of the cells with cytotoxic anti-DNA autoantibodies induced internucleosomal DNA fragmentation and Annexin V binding to the cell surface characteristic of apoptotic pathway of cell death. Expand
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