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Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells
The observed mitochondrial changes in COPD epithelium are potentially the consequence of long-term exposure to cigarette smoke, leading to impaired mitochondrial function and may play a role in the pathogenesis of COPD.
HER3, serious partner in crime: therapeutic approaches and potential biomarkers for effect of HER3-targeting.
ADCC responses and blocking of EGFR-mediated signaling and cell growth by combining the anti-EGFR antibodies imgatuzumab and cetuximab in NSCLC cells
- A. Kol, A. T. V. van Scheltinga, M. Pool, C. Gerdes, E. D. de Vries, S. de Jong
- Biology, ChemistryOncotarget
- 17 April 2017
It is found that imgatuzumab plus cetuximab leads to a strong downregulation of EGFR and superior cell growth inhibition in vitro without affecting antibody-induced ADCC responses, which support further clinical exploration of the antibody combination in EGFR wild-type NSCLC.
Extracellular domain shedding influences specific tumor uptake and organ distribution of the EGFR PET tracer 89Zr-imgatuzumab
High sEGFR levels can redirect 89Zr-imgatuzumab to the liver, in which case tumor visualization can be improved by increasing tracer antibody dose.
MAPK pathway activity plays a key role in PD‐L1 expression of lung adenocarcinoma cells
MAPK pathway activity plays a key role in EGF‐ and IFNγ‐induced PD‐L1 expression in lung adenocarcinoma without targetable genetic alterations and may present a target to improve the efficacy of immunotherapy.
Low-dose triple drug combination targeting the PI3K/AKT/mTOR pathway and the MAPK pathway is an effective approach in ovarian clear cell carcinoma.
89Zr-mAb3481 PET for HER3 tumor status assessment during lapatinib treatment
- M. Pool, A. Kol, S. de Jong, E. D. de Vries, M. L. Lub-de Hooge, A. T. V. Terwisscha van Scheltinga
- 5 September 2017
In vivo HER3 tumor status assessment after lapatinib treatment with zirconium-89 (89Zr)-labeled anti-HER3 antibody mAb3481 positron emission tomography (PET) showed high, HER3-specific tumor uptake, and such an approach might sensitively assess Her3 tumor heterogeneity and treatment response in patients.
A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer
The findings indicated that TGFβ plays a noncanonical role in coordinating immune responses against human tumors and suggest a potential role for CXCL13+CD103+CD8+ TILs in mediating B-cell recruitment and TLS formation in human tumors.
89Zr-Onartuzumab PET imaging of c-MET receptor dynamics
- M. Pool, A. T. V. Terwisscha van Scheltinga, A. Kol, D. Giesen, E. D. de Vries, M. L. Lub-de Hooge
- Medicine, ChemistryEuropean Journal of Nuclear Medicine and…
- 19 March 2017
Results show that 89Zr-onartuzumab PET effectively discriminates relevant changes in c-MET levels and could potentially be used clinically to monitor c- MET status.
Molecular Imaging of PD-L1 Expression and Dynamics with the Adnectin-Based PET Tracer 18F-BMS-986192
- T. Stutvoet, E. L. van der Veen, M. L. Lub-de Hooge
- Biology, MedicineThe Journal of Nuclear Medicine
- 1 May 2020
In mice, selumetinib lowered cellular, but not membrane, PD-L1 levels of tumors, and consequently, no treatment-induced change in 18F-BMS-986192 tumor uptake was observed and the tracer can discriminate a range of tumor cell PD- L1 membrane expression levels.