• Publications
  • Influence
The pathogenesis of rheumatoid arthritis.
  • A. Koch
  • Medicine
  • American journal of orthopedics
  • 1 July 2007
  • 1,429
  • 91
The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.
T cells infiltrating inflammatory sites are usually of the activated/memory type. The precise mechanism for the positioning of these cells within tissues is unclear. Adhesion molecules certainly playExpand
  • 1,369
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Interleukin-8 as a macrophage-derived mediator of angiogenesis.
Angiogenic factors produced by monocytes-macrophages are involved in the pathogenesis of chronic inflammatory disorders characterized by persistent angiogenesis. The possibility was tested thatExpand
  • 1,731
  • 28
Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing.
Angiogenesis is an essential component of normal wound repair, yet the primary mediators of wound angiogenesis have not been well described. The current study characterizes the contribution ofExpand
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Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1
ENDOTHELIAL adhesion molecules facilitate the entry of leukocytes into inflamed tissues. This in turn promotes neovascularization, a process central to the progression of rheumatoid arthritis, tumourExpand
  • 491
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Baricitinib in Patients with Refractory Rheumatoid Arthritis.
BACKGROUND In phase 2 studies, baricitinib, an oral Janus kinase 1 and 2 inhibitor, reduced disease activity in patients with rheumatoid arthritis who had not previously received treatment withExpand
  • 252
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Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis.
OBJECTIVE Since it is likely that monocytes utilize chemokines to migrate to the rheumatoid arthritis (RA) joint, we investigated the expression of C-C chemokine receptors (CCR) 1-6 and C-X-CExpand
  • 277
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Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis.
Cells within the synovial tissue may recruit mononuclear phagocytes into the synovial fluid and tissues of arthritic patients. We investigated the production of the chemotactic cytokine monocyteExpand
  • 491
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Fractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritis.
OBJECTIVE To examine the expression of the novel CX3C chemokine fractalkine (Fkn) and its receptor (CX3CR1) in rheumatoid arthritis (RA) and rat adjuvant-induced arthritis (AIA), a model of RA. Expand
  • 237
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Migration Inhibitory Factor Mediates Angiogenesis via Mitogen-Activated Protein Kinase and Phosphatidylinositol Kinase
Abstract— In this study, we investigated the effects of migration inhibitory factor (rhMIF) on angiogenesis-related signaling cascades and apoptosis in human endothelial cells (ECs). We show that inExpand
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