• Publications
  • Influence
Mitochondrial OPA1, apoptosis, and heart failure.
AIMS Mitochondrial fusion and fission are essential processes for preservation of normal mitochondrial function. We hypothesized that fusion proteins would be decreased in heart failure (HF), as theExpand
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Estrogen and the cardiovascular system.
Estrogen is a potent steroid with pleiotropic effects, which have yet to be fully elucidated. Estrogen has both nuclear and non-nuclear effects. The rapid response to estrogen, which involves aExpand
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HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway.
The heat shock proteins (HSP) are a highly conserved family of proteins with critical functions in protein folding, protein trafficking, and cell signaling. These proteins also protect the cellExpand
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HSP60 in heart failure: abnormal distribution and role in cardiac myocyte apoptosis.
Heat shock protein (HSP) 60 is a mitochondrial and cytosolic protein. Previously, we reported that HSP60 doubled in end-stage heart failure, even though levels of the protective HSP72 were unchanged.Expand
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CD11c/CD18 Expression Is Upregulated on Blood Monocytes During Hypertriglyceridemia and Enhances Adhesion to Vascular Cell Adhesion Molecule-1
  • R. Gower, H. Wu, +5 authors S. Simon
  • Biology, Medicine
  • Arteriosclerosis, thrombosis, and vascular…
  • 1 January 2011
Objective—Atherosclerosis is associated with monocyte adhesion to the arterial wall that involves integrin activation and emigration across inflamed endothelium. Involvement of &bgr;2-integrinExpand
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Extracellular Heat Shock Protein 60, Cardiac Myocytes, and Apoptosis
Rationale: Previously, we have found that changes in the location of intracellular heat shock protein (HSP)60 are associated with apoptosis. HSP60 has been reported to be a ligand of Toll-likeExpand
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Cytosolic Heat Shock Protein 60, Apoptosis, and Myocardial Injury
Background—Heat shock proteins (HSPs) are well known for their ability to “protect” the structure and function of native macromolecules, particularly as they traffic across membranes. Considering theExpand
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Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines.
OBJECTIVES This study was designed to investigate the appropriateness and complications of the use of spironolactone for heart failure (HF) in clinical practice. BACKGROUND Spironolactone wasExpand
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Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart.
Heat-shock proteins (HSPs) are an important family of endogenous, protective proteins. Overexpression of HSPs is protective against cardiac injury. Previously, we observed that dexamethasoneExpand
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Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes.
AIMS The molecular events leading from cardiomyocyte ischaemia to inflammatory cytokine production are not well understood. We previously found that heat shock protein 60 (HSP60) appeared inExpand
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