• Publications
  • Influence
Pharmacokinetics and relative bioavailability of fentanyl pectin nasal spray 100 - 800 µg in healthy volunteers.
TLDR
It is concluded that the pharmacokinetic profile of FPNS suggests this product is suitable for clinical investigation in breakthrough pain in cancer patients and is well tolerated.
Pharmacokinetic comparisons of three nasal fentanyl formulations; pectin, chitosan and chitosan-poloxamer 188.
TLDR
The FPNS formulation exhibited the most favorable nasal and general tolerability profiles and appears suitable for further investigation in breakthrough cancer pain management.
Bioavailability, safety and immunogenicity of biosimilar infliximab (BOW015) compared to reference infliximab.
TLDR
Bioequivalence of BOW015 to rIFX is demonstrated as 90% CIs for the study drug mean ratios of C(max), AUC(0-t), and AUC-0-inf were within the log-transformed ± 20% equivalence range of 0.80 - 1.25.
Impact of allergic rhinitis and its treatment on the pharmacokinetics of nasally administered fentanyl.
TLDR
Patients treated with FPNS will be unaffected by the development of allergic rhinitis; but, if oxymetazoline is prescribed, the patient would benefit from added supervision when oxymetzoline is started and stopped.
Norbuprenorphine and respiratory depression: Exploratory analyses with new lyophilized buprenorphine and sublingual buprenorphine
.
TLDR
Exploratory investigation found respiratory depression more strongly associated with norbuprenorphine than with buprenorphines, which accords with animal studies.
Randomised Comparison of a Novel Buprenorphine Oral Lyophilisate versus Existing Buprenorphine Sublingual Tablets in Opioid-Dependent Patients: A First-in-Patient Phase II Randomised Open Label
TLDR
Orally disintegrating buprenorphine oral lyophilisate wafer disintegrated rapidly and was found to have greater bioavailability with “bup-lyo” (but not norbuprenorphines) than with standard sub-lingual bupenorphine, suggesting that in supervised dosing contexts, rapidly disintegrating formulations may enable wider bup Renorphine prescribing.
Relationship between onset of pain relief and patient satisfaction with fentanyl pectin nasal spray for breakthrough pain in cancer.
TLDR
Earlier onset of pain relief resulted in greater patient satisfaction and overall relief of pain; between-treatment comparisons showed that FPNS provided earlier pain relief and greater satisfaction than IRMS or placebo.
Relationship between performance status and satisfaction with fentanyl pectin nasal spray
TLDR
This exploratory analysis examined the relationship between functional status and satisfaction with ability to use fentanyl pectin nasal spray (FPNS) for BTPc and concluded that the dispositivo FPNS proporciona un alto nivel of usabilidad independientemente del estado funcional.
An analysis of the variability of breakthrough pain intensity in patients with cancer.
TLDR
Baseline pain intensity scores during episodes of BTPc vary widely between patients, but vary little within individual patients; this supports the use of a consistent maintenance dosage of analgesia for B TPc, once it has been titrated to an effective dose.
...
...