A. Klug

Publications254
h-index84
Citations34,569
Highly Influential Citations850
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Mutation in the tau gene in familial multiple system tauopathy with presenile dementia.
TLDR
The results show that dysregulation of tau protein production can cause neurodegeneration and imply that the FTDP-17 gene is the tau gene, which has major implications for Alzheimer's disease and other tauopathies.
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Repetitive zinc‐binding domains in the protein transcription factor IIIA from Xenopus oocytes.
TLDR
Analysis of the amino acid sequence reveals nine tandem similar units, each consisting of approximately 30 residues and containing two invariant pairs of cysteines and histidines, the most common ligands for zinc in the 7S particle of Xenopus laevis oocytes, which suggests that the protein contains repetitive zinc‐binding domains.
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Involvement of histone H1 in the organization of the nucleosome and of the salt-dependent superstructures of chromatin
TLDR
It is concluded that H1 stabilizes the nucleosome and is located in the region of the exit and entry points of the DNA in H1-depleted chromatin, which has the form of an unravelled filament.
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Structure of the nucleosome core particle at 7 Å resolution
TLDR
The crystal structure of the nucleosome core particle has been solved to 7 Å resolution and the central turn of superhelix and H3 · H4 tetramer have dyad symmetry, but the H2A · H2B dimers show departures due to interparticle associations.
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The reconstruction of a three-dimensional structure from projections and its application to electron microscopy
A transmission electron micrograph is essentially a projection of the specimen in the direction of view. In order to reconstruct a three-dimensional image of the specimen, it is necessary to be able…
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Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.
TLDR
A substantially enriched preparation of Alzheimer paired helical filaments has been used as a starting point for biochemical studies and sequence analysis of these peptides was used to design oligonucleotide probes for cloning a cognate cDNA, which leads to its identification as human microtubule-associated tau protein.
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Solenoidal model for superstructure in chromatin.
  • J. Finch, A. Klug
  • Physics, Biology
    Proceedings of the National Academy of Sciences…
  • 1 June 1976
TLDR
It is proposed that the x-ray reflections at orders of 110 A observed in chromatin originate in the spacing between turns of the solenoid rather than that between nucleosomes along the nucleofilament.
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The structure of an oligo(dA)·oligo(dT) tract and its biological implications
TLDR
The crystal structure of a B-type DNA dodecamer containing a homopolymeric run of six A·T base pairs shows that this region possesses special structural features, including a system of bifurcated hydrogen bonds, which explains some of the properties of this simple homopolymer.
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The discovery of zinc fingers and their applications in gene regulation and genome manipulation.
  • A. Klug
  • Biology, Chemistry
    Annual review of biochemistry
  • 9 June 2010
TLDR
The zinc finger design is ideally suited for engineering proteins to target specific genes, and several applications of such engineered zinc finger proteins are described here, including some of therapeutic importance.
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Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.
TLDR
The proof that at least part of tau protein forms a component of the paired helical filament core opens the way to understanding the mode of formation of paired helicals filaments and thus, ultimately, the pathogenesis of Alzheimer disease.
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