• Publications
  • Influence
Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes.
Eosinophilia is an important indicator of various neoplastic and nonneoplastic conditions. Depending on the underlying disease and mechanisms, eosinophil infiltration can lead to organ dysfunction,Expand
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Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis
BACKGROUND Eosinophilic granulomatosis with polyangiitis is an eosinophilic vasculitis. Mepolizumab, an anti–interleukin‐5 monoclonal antibody, reduces blood eosinophil counts and may have value inExpand
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Refining the definition of hypereosinophilic syndrome.
Because of advances in our understanding of the hypereosinophilic syndrome (HES) and the availability of novel therapeutic agents, the original criteria defining these disorders are becomingExpand
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Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources
The Human Phenotype Ontology (HPO)—a standardized vocabulary of phenotypic abnormalities associated with 7000+ diseases—is used by thousands of researchers, clinicians, informaticians and electronic health record systems. Expand
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Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy.
BACKGROUND Hypereosinophilic syndrome (HES) is a heterogeneous group of rare disorders defined by persistent blood eosinophilia > or =1.5 x 10(9)/L, absence of a secondary cause, and evidence ofExpand
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Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report.
Hypereosinophilic syndromes are a heterogeneous group of uncommon disorders characterized by the presence of marked peripheral blood eosinophilia, tissue eosinophilia, or both, resulting in a wideExpand
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How I treat hypereosinophilic syndromes.
Hypereosinophilic syndromes (HESs) are a group of rare disorders characterized by peripheral blood eosinophilia of 1.5 × 10(9)/L or higher and evidence of end organ manifestations attributable to theExpand
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Treatment of patients with the hypereosinophilic syndrome with mepolizumab.
BACKGROUND The hypereosinophilic syndrome is a group of diseases characterized by persistent blood eosinophilia, defined as more than 1500 cells per microliter with end-organ involvement and noExpand
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The role of eosinophils in host defense against helminth parasites.
  • A. Klion, T. Nutman
  • Biology, Medicine
  • The Journal of allergy and clinical immunology
  • 2004
The precise function of eosinophils in parasitic infection in vivo remains poorly understood despite eosinophils having been shown to be potent effectors in killing parasites in vitro. Although itExpand
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Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field
Eosinophils and their products play an essential role in the pathogenesis of various reactive and neoplastic disorders. Depending on the underlying disease, molecular defect and involved cytokines,Expand
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