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Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis
- A. Akinc, Mini Thomas, A. Klibanov, R. Langer
- BiologyThe journal of gene medicine
- 1 May 2005
The relatively high transfection efficiency of polyethylenimine (PEI) vectors has been hypothesized to be due to their ability to avoid trafficking to degradative lysosomes. According to the proton…
Ultrahigh-throughput screening in drop-based microfluidics for directed evolution
- J. Agresti, E. Antipov, D. Weitz
- BiologyProceedings of the National Academy of Sciences
- 8 February 2010
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Designing surfaces that kill bacteria on contact
- J. Tiller, C. Liao, K. Lewis, A. Klibanov
- Materials Science, BiologyProceedings of the National Academy of Sciences…
- 15 May 2001
TLDR
Improving enzymes by using them in organic solvents
- A. Klibanov
- Chemistry, MedicineNature
- 11 January 2001
The technological utility of enzymes can be enhanced greatly by using them in organic solvents rather than their natural aqueous reaction media. Studies over the past 15 years have revealed not only…
Peroxidase-Catalyzed Removal of Phenols from Coal-Conversion Waste Waters
- A. Klibanov, TSU-MAN Tu, Kevin P. Scott
- Biology, EngineeringScience
- 15 July 1983
A novel, enzymatic approach has been developed for the removal of phenols from coal-conversion aqueous effluents. Treatment with horseradish peroxidase and hydrogen peroxide precipitates 97 to 99…
Why are enzymes less active in organic solvents than in water?
- A. Klibanov
- BiologyTrends in biotechnology
- 1 March 1997
Enzymatic catalysis in nonaqueous solvents.
- A. Zaks, A. Klibanov
- Chemistry, BiologyThe Journal of biological chemistry
- 5 March 1988
Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres
- K. Fu, D. W. Pack, A. Klibanov, R. Langer
- ChemistryPharmaceutical Research
- 2004
TLDR
Stabilization of enzymes against thermal inactivation.
- A. Klibanov
- BiologyAdvances in applied microbiology
- 1983
Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung.
- Mini Thomas, James J. Lu, Q. Ge, Chengcheng Zhang, Jianzhu Chen, A. Klibanov
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 19 April 2005
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