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- Publications
- Influence
Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis
- A. Akinc, Mini P. Thomas, A. Klibanov, R. Langer
- Medicine, Biology
- The journal of gene medicine
- 1 May 2005
The relatively high transfection efficiency of polyethylenimine (PEI) vectors has been hypothesized to be due to their ability to avoid trafficking to degradative lysosomes. According to the proton… Expand
Ultrahigh-throughput screening in drop-based microfluidics for directed evolution
- J. Agresti, E. Antipov, +7 authors D. Weitz
- Biology, Materials Science
- Proceedings of the National Academy of Sciences
- 8 February 2010
The explosive growth in our knowledge of genomes, proteomes, and metabolomes is driving ever-increasing fundamental understanding of the biochemistry of life, enabling qualitatively new studies of… Expand
Designing surfaces that kill bacteria on contact
- J. Tiller, C. J. Liao, K. Lewis, A. Klibanov
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 15 May 2001
Poly(4-vinyl-N-alkylpyridinium bromide) was covalently attached to glass slides to create a surface that kills airborne bacteria on contact. The antibacterial properties were assessed by spraying… Expand
Peroxidase-Catalyzed Removal of Phenols from Coal-Conversion Waste Waters
- A. Klibanov, T. Tu, K. Scott
- Chemistry, Medicine
- Science
- 15 July 1983
A novel, enzymatic approach has been developed for the removal of phenols from coal-conversion aqueous effluents. Treatment with horseradish peroxidase and hydrogen peroxide precipitates 97 to 99… Expand
Enzymatic catalysis in nonaqueous solvents.
- A. Zaks, A. Klibanov
- Chemistry, Medicine
- The Journal of biological chemistry
- 5 March 1988
Subtilisin and alpha-chymotrypsin vigorously act as catalysts in a variety of dry organic solvents. Enzymatic transesterifications in organic solvents follow Michaelis-Menten kinetics, and the values… Expand
Why are enzymes less active in organic solvents than in water?
- A. Klibanov
- Chemistry, Medicine
- Trends in biotechnology
- 1 March 1997
In order to exploit fully the biotechnological opportunities afforded by nonaqueous enzymology, the issue of often drastically diminished enzymatic activity in organic solvents compared with that in… Expand
Non-viral gene therapy: polycation-mediated DNA delivery
- M. Thomas, A. Klibanov
- Biology, Medicine
- Applied Microbiology and Biotechnology
- 29 April 2003
Gene therapy, i.e., the expression in cells of genetic material with therapeutic activity, holds great promise for the treatment of human diseases. A delivery vehicle (vector), of either viral or… Expand
Stabilization of enzymes against thermal inactivation.
- A. Klibanov
- Chemistry, Medicine
- Advances in applied microbiology
- 1983
Publisher Summary In order to be suitable for technological applications, catalysts should be stable under operational conditions for weeks or months. With continuous research it is found that… Expand
The effect of water on enzyme action in organic media.
- A. Zaks, A. Klibanov
- Chemistry, Medicine
- The Journal of biological chemistry
- 15 June 1988
Three model, unrelated enzymes (yeast alcohol oxidase, mushroom polyphenol oxidase, and horse liver alcohol dehydrogenase) were found to be catalytically active in a variety of organic solvents. For… Expand