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Drug discovery from medicinal plants.
TLDR
Several compounds from tropical rainforest plant species with potential anticancer activity have been identified and several compounds, mainly from edible plant species or plants used as dietary supplements, that may act as chemopreventive agents are isolated.
Drug Discovery from Plants
TLDR
In the future, plant-derived compounds will still be an essential aspect of the therapeutic array of medicines available to the physician, particularly with the availability of new hyphenated analytical methods such as LC-NMR-MS and LC-SPE-N MR to accelerate their future discovery.
Selective Induction of Apoptosis of Human Oral Cancer Cell Lines by Avocado Extracts Via a ROS-Mediated Mechanism
TLDR
Treatment of human oral cancer cell lines containing high levels of reactive oxygen (ROS) with D003 increased ROS levels twofold to threefold and induced apoptosis, suggesting that perturbing the ROS levels in human oral cancers cell lines may be a key factor in selective apoptosis and molecular targeting for chemoprevention by phytochemicals.
Drug discovery from natural sources
TLDR
These approved substances, representative of very wide chemical diversity, together with several other natural products or their analogs undergoing clinical trials, continue to demonstrate the importance of compounds from natural sources in modern drug discovery efforts.
The continuing search for antitumor agents from higher plants.
TLDR
A single chemical entity antineoplastic agents from higher plants that are currently in clinical trials as cancer chemotherapy drug candidates are described, representative of a wide structural diversity.
Multiple Berry Types Prevent N-nitrosomethylbenzylamine-Induced Esophageal Cancer in Rats
TLDR
Seven berry types were about equally capable of inhibiting tumor progression in the rat esophagus in spite of known differences in levels of anthocyanins and ellagitannins.
Drug Discovery From Natural Sources
TLDR
These approved substances, representative of very wide chemical diversity, together with several other natural products or their analogs undergoing clinical trials, continue to demonstrate the importance of compounds from natural sources in modern drug discovery efforts.
Natural products as aromatase inhibitors.
TLDR
A thorough review of the literature regarding natural product extracts and secondary metabolites of plant, microbial, and marine origin that have been shown to exhibit aromatase inhibitory activity is presented herein.
Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement.
TLDR
Progress made in the structural characterization of the chemical constituents of mangosteen, as well as the biological activity of pure constituents of this species and synthetic methods for the mangosten xanthones are dealt with.
Chemopreventive characteristics of avocado fruit.
TLDR
It is suggested that individual and combinations of phytochemicals from the avocado fruit may offer an advantageous dietary strategy in cancer prevention and target multiple signaling pathways and increase intracellular reactive oxygen leading to apoptosis.
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