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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
As a result of bioassay–guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma–specific cytotoxic agent and antitumour activity was mediated by the induction of apoptosis.
Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen).
- H. Jung, B. Su, W. Keller, R. Mehta, A. Kinghorn
- Biology, MedicineJournal of agricultural and food chemistry
- 18 February 2006
Except for compound 2, which was isolated as a minor component, the antioxidant activities of all isolates were determined using authentic and morpholinosydnonimine-derived peroxynitrite methods, and compounds 1, 8, 10, 11, and 13 were the most active.
Cytotoxic and antimalarial constituents of the roots of Eurycoma longifolia.
- L. Kardono, C. Angerhofer, S. Tsauri, K. Padmawinata, J. Pezzuto, A. Kinghorn
- Biology, ChemistryJournal of natural products
- 1 September 1991
By bioactivity-directed fractionation, five cytotoxic constituents have been characterized from the roots of Eurycoma longifolia and compounds 5 and 7 were found to demonstrate significant antimalarial activity as judged by studies conducted with cultured Plasmodium falciparum strains.
Special Problems with the Extraction of Plants
Evaluation of the antioxidant potential of natural products.
Of these substances, the hydroxystilbenes piceatannol and transresveratrol have thus far been shown to inhibit carcinogen-induced preneoplastic lesion formation in the mouse mammary gland organ culture model.
Current status of stevioside as a sweetening agent for human use
Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.
- G. Tan, J. Pezzuto, A. Kinghorn, S. Hughes
- Chemistry, BiologyJournal of natural products
- 6 August 1991
The bioassay system was shown to be generally applicable to both pure natural products and plant extracts, and proved useful in directing an isolation procedure with Plumeria rubra to yield fulvoplumierin as an active compound.
Metabolically activated steviol, the aglycone of stevioside, is mutagenic.
- J. Pezzuto, C. Compadre, S. Swanson, D. Nanayakkara, A. Kinghorn
- BiologyProceedings of the National Academy of Sciences…
- 1 April 1985
It is clear that a metabolite of an integral component of stevioside is mutagenic; structural features of requisite importance for the expression of mutagening activity include a hydroxy group at position 13 and an unsaturated bond joining the carbon atoms at positions 16 and 17.
An anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of Morinda citrifolia (noni).
- A. Pawlus, B. Su, W. Keller, A. Kinghorn
- Chemistry, MedicineJournal of natural products
- 16 November 2005
Bioassay-guided fractionation of a dichloromethane-soluble partition of a MeOH extract of noni fruits has led to the isolation of an extremely potent quinone reductase inducer, 2-methoxy-1,3,6-trihydroxyanthraquinone (1).