• Publications
  • Influence
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
TLDR
It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans. Expand
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
TLDR
As a result of bioassay–guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma–specific cytotoxic agent and antitumour activity was mediated by the induction of apoptosis. Expand
Cytotoxic and antimalarial constituents of the roots of Eurycoma longifolia.
TLDR
By bioactivity-directed fractionation, five cytotoxic constituents have been characterized from the roots of Eurycoma longifolia and compounds 5 and 7 were found to demonstrate significant antimalarial activity as judged by studies conducted with cultured Plasmodium falciparum strains. Expand
Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen).
TLDR
Except for compound 2, which was isolated as a minor component, the antioxidant activities of all isolates were determined using authentic and morpholinosydnonimine-derived peroxynitrite methods, and compounds 1, 8, 10, 11, and 13 were the most active. Expand
Evaluation of the antioxidant potential of natural products.
TLDR
Of these substances, the hydroxystilbenes piceatannol and transresveratrol have thus far been shown to inhibit carcinogen-induced preneoplastic lesion formation in the mouse mammary gland organ culture model. Expand
Metabolically activated steviol, the aglycone of stevioside, is mutagenic.
TLDR
It is clear that a metabolite of an integral component of stevioside is mutagenic; structural features of requisite importance for the expression of mutagening activity include a hydroxy group at position 13 and an unsaturated bond joining the carbon atoms at positions 16 and 17. Expand
Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity.
Purification of a n-BuOH-soluble partition of the MeOH extract of Morinda citrifolia (Noni) fruits led to the isolation of two new iridoid glucosides, 6alpha-hydroxyadoxoside (1) andExpand
Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris.
Two cytotoxic rocaglate derivatives possessing an unusual dioxanyloxy unit, silvestrol (1) and episilvestrol (2), were isolated from the fruits and twigs of Aglaia silvestris by bioassay-guidedExpand
...
1
2
3
4
5
...