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Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration.
- Y. Ishida, A. Kimura, +5 authors N. Mukaida
- Biology, Medicine
- The American journal of pathology
- 1 March 2007
We investigated the pathogenic roles of CC chemokine ligand (CCL)3 and its receptors, CC chemokine receptor (CCR)1 and CCR5, in bleomycin (BLM)-induced pulmonary fibrosis (PF). An intratracheal… Expand
Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen‐induced acute liver injury
- Y. Ishida, T. Kondo, A. Kimura, K. Tsuneyama, T. Takayasu, N. Mukaida
- European journal of immunology
- 1 April 2006
Neutrophils and macrophages infiltrate after acetaminophen (APAP)‐induced liver injury starts to develop. However, their precise roles still remain elusive. In untreated and control IgG‐treated… Expand
Retrospective study on suicidal cases by sharp force injuries.
- Setsuko Fukube, T. Hayashi, +4 authors T. Kondo
- Journal of forensic and legal medicine
- 1 April 2008
A total of 65 suicidal cases due to sharp force injuries (cut and/or stab wounds) were investigated. Suicide by sharp force injuries accounted for 2.5% of all suicides in our prefecture during… Expand
Cholestenoic acids regulate motor neuron survival via liver X receptors.
- Spyridon Theofilopoulos, W. Griffiths, +33 authors Yuqin Wang
- Biology, Medicine
- The Journal of clinical investigation
- 3 November 2014
Cholestenoic acids are formed as intermediates in metabolism of cholesterol to bile acids, and the biosynthetic enzymes that generate cholestenoic acids are expressed in the mammalian CNS. Here, we… Expand
Mutations in the Canalicular Multispecific Organic Anion Transporter (cMOAT) Gene, a Novel ABC Transporter, in Patients with Hyperbilirubinemia II/Dubin-Johnson Syndrome
Members of the ATP-binding cassette (ABC) transporter superfamily are mutated to cause diseases that include cystic fibrosis, hyperinsulinemia, adrenoleukodystrophy, Stargardt disease and multidrug… Expand
Degradation profile of mRNA in a dead rat body: basic semi-quantification study.
To profile postmortem degradation of mRNA, total RNA was extracted, at given postmortem intervals, from the brain, lung, heart and liver of rats left at 20 degrees C. In electrophoretic analysis,… Expand
Forensic application of VEGF expression to skin wound age determination
- T. Hayashi, Y. Ishida, A. Kimura, T. Takayasu, W. Eisenmenger, T. Kondo
- International Journal of Legal Medicine
- 3 August 2004
An immunohistochemical study combined with morphometry was carried out to examine the time-dependent expression of vascular endothelial growth factor (VEGF) using 53 human skin wounds with different… Expand
Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells
&NA; Foxp3 controls the development and function of regulatory T (Treg) cells, but it remains elusive how Foxp3 functions in vivo. Here, we established mouse models harboring three unique missense… Expand
Emergency center ultrasonography in the evaluation of hemoperitoneum: a prospective study.
The reliability of ultrasonographic detection (US) of hemoperitoneum in blunt abdominal trauma was evaluated in a prospective study of 72 patients. Independent of the examiner, sensitivity,… Expand
Essential Involvement of IFN-γ in Clostridium difficile Toxin A-Induced Enteritis1
Clostridium difficile has emerged as the important causative agent of antibiotics-associated pesudomembranous colitis; especially its toxin A is presumed to be responsible for the colitis. We… Expand