Synthesis of purines under possible primitive earth conditions. I. Adenine from hydrogen cyanide.
- J. Oró, A. Kimball
- ChemistryArchives of Biochemistry and Biophysics
- 1 August 1961
Synthesis of purines under possible primitive earth conditions. II. Purine intermediates from hydrogen cyanide.
- J. Oró, A. Kimball
- ChemistryArchives of Biochemistry and Biophysics
- 1 February 1962
Amino acid synthesis from formaldehyde and hydroxylamine.
- J. Oró, A. Kimball, R. Fritz, F. Master
- ChemistryArchives of Biochemistry and Biophysics
- 1 November 1959
Chemical suppression of the immune response.
- A. Kimball
- MedicinePrimates in medicine
- 1968
Deamination of arabinosyladenine by adenosine deaminase and inhibition by arabinosyl-6-mercaptopurine.
- D. L. Chao, A. Kimball
- BiologyCancer Research
- 1 August 1972
Summary 6-Mercapto-9-(β-d-arabinofuranosyl)purine (ara-6-MP) was found to be a competitive inhibitor of L1210 adenosine deaminase when β-d-arabinosyladenine (ara-A) was used as substrate…
Studies of Rhodium(II) Carboxylates as Potential Antitumor Agents 1
- A. Erck, L. Rainen, J. Whileyman, I. Chang, A. Kimball, J. Bear
- Biology, ChemistryProceedings of the Society for Experimental…
- 1 April 1974
Rhodium (II) acetate and rhodium(II) propionate were found to be antineoplastic agents that inhibited DNA and RNA synthesis and block de novo purine biosynthesis.
Mechanism of action of tetra-mu-carboxylatodirhodium(II) in L1210 tumor suspension culture.
- R. Howard, A. Kimball, J. Bear
- Chemistry, BiologyCancer Research
- 1 July 1979
Flow microfluorometric analysis of the drug-treated cells revealed an arrest of cellular development during the G2 phase of the cell cycle which is consistent with the observed inhibition of protein synthesis.
Interaction of Rhodium(II) carboxylates with molecules of biologic importance.
- J. Bear, H. Gray, A. Kimball
- Chemistry, BiologyCancer chemotherapy reports
- 1 May 1975
Equilibrium dialysis studied showed that rhodium(II) acetate-1-14C binds to single stranded DNA, poly-A, ribonuclease A, and bovine serum albumin but not to highly polymerized native calf thymus DNA,Poly-G, or poly-C, while sedimentation and viscosity measurements indicate a high degree of intramolecular crosslinking in the rhodio-A/poly-A complex.
Inhibitory effects of the arabinosides of 6-mercaptopurine and cytosine on purine and pyrimidine metabolism.
- A. Kimball, B. Bowman, P. Bush, J. Herriot, G. Lepage
- Biology, ChemistryCancer Research
- 1 July 1966
The drug synergism given by combinations of azaserine and ara-6-MP suggests that a sequential block occurs in the formation of deoxycytidylates from uridylate.
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