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Synthesis of purines under possible primitive earth conditions. I. Adenine from hydrogen cyanide.
Abstract Adenine has been synthesized in substatial amounts by heating a solution of hydrogen cyanide (1 to 15 M) in aqueous ammonia for one or several days at moderate temperatures (27 ° to 100 °).… Expand
Synthesis of purines under possible primitive earth conditions. II. Purine intermediates from hydrogen cyanide.
Abstract In addition to adenine, the supernatant solution from the product of the base-catalyzed condensation of hydrogen cyanide in aqueous ammonia contains several purine precursors such as… Expand
Deamination of arabinosyladenine by adenosine deaminase and inhibition by arabinosyl-6-mercaptopurine.
Summary 6-Mercapto-9-(β-d-arabinofuranosyl)purine (ara-6-MP) was found to be a competitive inhibitor of L1210 adenosine deaminase when β-d-arabinosyladenine (ara-A) was used as substrate… Expand
Studies of Rhodium(II) Carboxylates as Potential Antitumor Agents 1
- A. Erck, L. Rainen, J. Whileyman, I. Chang, A. Kimball, J. Bear
- Chemistry, Medicine
- Proceedings of the Society for Experimental…
- 1 April 1974
Summary Rhodium (II) acetate and rhodium (II) propionate were found to be antineoplastic agents. Both compounds inhibited DNA and RNA synthesis. The rhodium(II) propionate was also found to block de… Expand
Mechanism of action of tetra-mu-carboxylatodirhodium(II) in L1210 tumor suspension culture.
The effect of tetrakis-mu-methoxyacetato, tetra-mu-acetato, tetra-mu-propionato, and tetra-mu-butyratodirhodium(II) on the proliferation and macromolecular synthesis of leukemia L1210 cells in… Expand
Interaction of Rhodium(II) carboxylates with molecules of biologic importance.
Rhodium(II) acetate, propionate, and butyrate showed a considerable variation in their antitumor activity against Ehrlich ascites tumor cells in mice, with the butyrate complex being the most active.… Expand
Inhibitory effects of the arabinosides of 6-mercaptopurine and cytosine on purine and pyrimidine metabolism.
The influences on metabolism in ascites tumor cells of azaserine, 1-β-d-arabinofuranosylcytosine (ara-C), and 9-β-d-arabinofuranosyl-9- H -purine-6-thiol (ara-6-MP) were studied and compared.… Expand