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Synthesis of purines under possible primitive earth conditions. I. Adenine from hydrogen cyanide.
  • J. Oró, A. Kimball
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • 1 August 1961
Abstract Adenine has been synthesized in substatial amounts by heating a solution of hydrogen cyanide (1 to 15 M) in aqueous ammonia for one or several days at moderate temperatures (27 ° to 100 °).Expand
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Synthesis of purines under possible primitive earth conditions. II. Purine intermediates from hydrogen cyanide.
  • J. Oró, A. Kimball
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • 1 February 1962
Abstract In addition to adenine, the supernatant solution from the product of the base-catalyzed condensation of hydrogen cyanide in aqueous ammonia contains several purine precursors such asExpand
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Chemical suppression of the immune response.
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Deamination of arabinosyladenine by adenosine deaminase and inhibition by arabinosyl-6-mercaptopurine.
Summary 6-Mercapto-9-(β-d-arabinofuranosyl)purine (ara-6-MP) was found to be a competitive inhibitor of L1210 adenosine deaminase when β-d-arabinosyladenine (ara-A) was used as substrateExpand
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Studies of Rhodium(II) Carboxylates as Potential Antitumor Agents 1
Summary Rhodium (II) acetate and rhodium (II) propionate were found to be antineoplastic agents. Both compounds inhibited DNA and RNA synthesis. The rhodium(II) propionate was also found to block deExpand
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Mechanism of action of tetra-mu-carboxylatodirhodium(II) in L1210 tumor suspension culture.
The effect of tetrakis-mu-methoxyacetato, tetra-mu-acetato, tetra-mu-propionato, and tetra-mu-butyratodirhodium(II) on the proliferation and macromolecular synthesis of leukemia L1210 cells inExpand
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Prebiotic and biochemical evolution
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Interaction of Rhodium(II) carboxylates with molecules of biologic importance.
Rhodium(II) acetate, propionate, and butyrate showed a considerable variation in their antitumor activity against Ehrlich ascites tumor cells in mice, with the butyrate complex being the most active.Expand
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Inhibitory effects of the arabinosides of 6-mercaptopurine and cytosine on purine and pyrimidine metabolism.
The influences on metabolism in ascites tumor cells of azaserine, 1-β-d-arabinofuranosylcytosine (ara-C),[2][1] and 9-β-d-arabinofuranosyl-9- H -purine-6-thiol (ara-6-MP) were studied and compared.Expand
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DNA-dependent RNA polymerase.
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